脑钠肽及冠脉造影病变关系探究

《脑钠肽及冠脉造影病变关系探究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、脑钠肽及冠脉造影病变关系探究作者：邓新桃，石桂良，郑金国，赵建祥，洪渊，马根山【摘要】目的：观察血清脑钠肽(BNP)浓度的变化与冠脉病变之间的关系。方法：临床拟诊冠心病患者374例，按冠脉造影结果分为阳性组(235例)、阴性组(139例)，并根据冠状动脉病变的范围分为单支血管病变组(64例)、双支血管病变组(79例)和三支血管病变组(92例)，均于入院时测定血清中BNP、C反应蛋白(CRP)水平，进行统计分析。结果:阳性组BNP浓度为(115.91±53.64)pg/ml,阴性组(37.70±33.61)pg/ml,两组间差异有统计学

2、意义,P<；0.01；单支病变组浓度为(96.49±12.09)pg/ml>双支病变组浓度为(113.49±11.94)pg/ml.三支病变组浓度为(121.80±9.77)pg/ml,单因素方差分析示组间差异有统计学意义，P<；0.05；多因素Logistic分析结果示BNP水平与冠脉造影(CAG)诊断冠心病(CHD)结果明显相关。结论：血清BNP水平是冠心病的独立危险因素，其水平的增高对冠心病患者病变累及的程度可能有一定临床参考价值，且BNP是较CRP更敏感的指标。【关键词】脑钠肽；C反应蛋白；冠心病；冠状动脉造影[Abs

3、tract]Objective：Toinvestigatetherelationshipbetweentheserumbrainnatriureticpeptide(BNP)concentrationvariancesandcoronaryangiographydisease・Methods：AccordingtotheresuItsofcoronaryangiography,374casesweredividedintoCHDgroup(235cases)andtheNonCHDgroup(139cases).Accordingto

4、thescopeofcoronaryarterydisease,theCHDgroupweredividedintosinglevesseldiseasegroup(64cases),doublevesseldiseasegroup(79cases)andthreevesseldiseasegroup(92cases).AllcaseswererespectivelymeasuredserumBNPandCRPlevelsonadmission,thenanalyzed.ResuIts：LevelsofserumBNPoftheCHD

5、group(115.91±53.64)pg/mlweresignificantlyelevatedcomparedwithNonCHDgroup(37.70±33.61)pg/ml,P<；0.01.LevelsofserumBNPofthesinglevesseldiseasegroupis(96・49±12.09)pg/ml,doublevesseldiseasegroup(113.49±11.94)pg/ml,threelesions(121.80+9.77)pg/ml・OnewayANOVAshowedsignificant

6、differencesamonggroups,P&It；0.05.MultinomiallogisticanalysisshowedBNPlevelssignificantlycorrelatedCHD.Conelusion：SerumBNPlevelwasanindependentriskfactorforcoronaryheartdisease・TheirlevelsincreasedinCHDpatientsmayhavesomedegreeofclinicalreferencevalueforlesionsinvolvingt

7、heextentofcoronaryartery,andBNPwasamoresensitiveindicatorthanCRP・_Keywords]brainnatriureticpeptide；Creactiveprotein；coronaryheartdisease；coronaryangiography冠心病的各种危险因素不断地被发现和证明，且均已成为预防和治疗冠心病的关键靶点。脑钠肽(brainnatriureticpeptide,BNP)与心血管疾病的关系以及作用机制正成为近年研究的热点。C反应蛋白(Creactivepr

8、oteinCRP)水平的升高和造影所示冠脉病变数相关，病变数越多，血CRP水平越高。本研究测定冠心病患者血浆BNP、CRP水平，旨在探讨它们对冠心病短期预后的预测价值及两者之间的相关性，为评价冠心病的病情提供新的理论依据