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1、立宝舒卡波姆眼用凝胶治疗干眼的临床观察作者：邓志宏，赵少贞，张未女札赵小云单位：中国天津市，天津医科大学眼科中心【摘要】目的：通过观察干眼症患者使用2g/L立宝舒卡波姆眼用凝胶(简称立宝舒)前后，患者的主观症状、视力、干眼实验室检查结果以及药物的耐受性，评估立宝舒对干眼症的疗效。方法：选择干眼症患者100例200眼予以2g/L立宝舒卡波姆眼用凝胶滴双眼，4次/d。观察就诊当天、用药7,14,28d后患者主观症状：T燥感、异物感、酸痛感、眼疲劳、眼红、畏光；视力、T眼实验室检查：泪膜破裂吋间(bre
2、akuptime,BUT).荧光素染色、SchinnerI试验、SchinnerII试验、脸板腺功能检杳结果以及患者用药的耐受性。结果：用药7d后，患者的干燥感、异物感、酸痛感、眼疲劳、眼红、畏光等主观症状的分级与用药前有显著差异(P<0.01),随着川药时间的延长，6种主观症状明显缓解；但患者不同时间的视力无明显差异(P>0.05)o用药后患者的BUT及SchirmerI,SchirmerII值与用药前有显著差异(P<0.01),并H_随着川药时间的延长，患者BUT及Schin
3、YierI,SchirmerII值明显延长；但不同时间的睑板腺功能分级无明显差异(P>；0.05)；川药后患者荧光素染色分级及汨膜脂质干涉Yakoi分级与用药询有显著差异(P<0.01)o所有观察病例中未发现明显不耐受药物的患者。结论：2g/L的立宝舒卡波姆眼用凝胶可以明显改善干眼患者的眼部症状和干眼实验室检杏结果，药物耐受性好，但对患者视力和睑板腺功能无明显改善作用。【关键词】干眼立宝舒人工泪液ClinicalstudyofLiposicintreatingdryeyepatients
4、ZhiHongDeng,ShaoZhenZhao,WeiJuanZhang,XiaoYunZhaoEyeCenterofTianjinMedicalUniversity,Tianjin300070,ChinaAbstractAIM:ToinvestigatetheeffectofLiposicondryeye,wesurveythesubjectivesymptoms,visualacuity,andresultsoflaboratoryexaminationindryeyepatientsbef
5、oreandaftertreatedwithLiposic.METHODS:Onehundreddryeyepatients(200eyes)weretreatedLiposic,fourtimesaday.Thesubjectivesymptoms,laboratoryexaminationofdryeyeandtoleranceofpatientswereobservedonthevisitday,7,14,28daysaftertreatedwithLiposic.Thesubjective
6、symptomsincludedthedrysensation,foreignbodysensation,acliingpain,asthenopiaandphotophobia,andthelaboratoryexaminationofdryeyeincludedBUTtest,SchirmerItest(SIt),SchirmerIItest(SIIt),fluoresceinstaining,andexaminationinthefunctionofmeibomiangland.RESULT
7、S:AftertreatedwithLiposicfor7days,thesubjectivesymptomsofdryeyepatientswererelievedcomparedwithuntreatedpatients(P<0.01),butnosignificantdifferencecouldbeobservedinthevisualacuitybetweentreatedanduntreatedpatients(P>0.05).TheresultsofBUT,SItandS
8、IIt,fluoresceinstainingandYakoigradewerealsoimprovedaftertreatedwithLiposic(P<0.01).Butbutnosignificantdifferencecouldbeobservedinthefunctiontestofmeibomianglandbetweentreatedanduntreatedpatients(P>0.05).AllpatientsshowedgoodtolerancetoL
