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ID:44595331
大小:74.16 KB
页数:10页
时间:2019-10-23
《西酞普兰联合阿立哌唑治疗抑郁症对照探究》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、西駄普兰联合阿立哌坐治疗抑郁症对照探【摘要】目的探讨西駄普兰联合阿立哌哇治疗抑郁症的临床疗效及安全性。方法将61例抑郁症患者随机分为两组,均给予西駄普兰治疗,研究组联合阿立哌哩治疗,观察8Wo于治疗前及治疗第1w、2w、4w、6w、8w末采用汉密顿抑郁量表、临床疗效总评量表、副反应量表评定临床疗效和不良反应。结果研究组治疗5d〜19d显效,对照组13d〜31d显效,两组比较有显著性差异(t=2.25,P<0.05);汉密顿抑郁量表评分研究组治疗1w末起,对照组2w末起较治疗前有极显著性下降(PV0.01),且随治疗时间的延续均呈持续性下降;研究组治疗1w、2w、4w、6w末较对照
2、组下降显著(P均<0.05),治疗8w末无显著性差异(P均〉0.05);临床疗效总评量表评分,治疗8w末两组均较治疗前有极显著性下降(卩均<0.01);两组不良反应均轻微。结论西駄普兰联合小剂量阿立哌哩治疗抑郁症疗效显著,起效快,安全性高,依从性好。【关键词】抑郁症;西駄普兰;阿立哌哇[Abstract]ObjectiveToexploretheclinicalefficacyandsafetyofcitalopramcombinedwitharipiprazoleinthetreatmentofdepression.MethodsSixtyonedepressivepatien
3、tswererandomlyassignedtoresearchreceivingcitalopramcombinedwitharipiprazoleandcontrolgroupdoingcitalopramfor8weeks,clinicalefficacieswereassessedwiththeHamiltonDepressionScale(HAMD)andtheClinicalGlobalImpression(CGI)andadverseeffectswiththeTreatmentEmergentSymptomScale(TESS)beforetreatmentand
4、attheendsofthe1st,2nd,4th,6thand8thweektreatment・ResultsTheresearchgrouptookeffectswithin5〜9daysandthecontroldid13〜31days,whichshowedsignificantdifference(P<;0.05);comparedwithpretreatment,theHAMDscoreloweredverymoresignificxantlyintheresearchsincetheendofthe1stweekandinthecontrolsincethe2n
5、d(P<;0.01),andcontinouslydidalongwithtreatmentlasting;attheendsofthe1st,2nd,4thand6thweekthecontrolloweredmoresignificantlythantheresearchdid(P<;0.05),attheendofthe8thweektherewasnodifferncebetweenthe2groups(P>;0.05);theCGIscoresofbothgroupsloweredverymoresignificantlyattheendofthe8thwe
6、ekcomparedwithpretreatment(P<;0.01)・Adverseeffectsofbothgroupsweremilder・ConclusionCitalopramcombinedwithsmalldosearipiprazoletakeseffectsfasterandhasmoersignficantefficacy,highersafetyandbettercomplianceinthetreatmentofdepression.[Keywords]Depression;citalopram;aripiprazol西駄普兰治疗抑郁症已取得较好的疗效
7、,但西駄普兰起效相对较慢,通常为2w,部分患者需达4w才能显效[1]。药物起效快慢有可能影响患者的服药依从性,因为绝大多数患者希望在接受治疗后短期内能迅速显效,部分患者可因短期内未显效而放弃治疗。为此,我们采用西駄普兰联合小剂量阿立哌吐治疗抑郁症进行了对照研究,评价其治疗抑郁症起效时间,临床疗效及安全性。1对象与方法1.1对象选取2006年3月〜12月在我院门诊和住院治疗的抑郁症患者为研究对象。入组标准:(1)符合《中国精神障碍分类与诊断标准》第3版(CCMD3)抑郁症诊断标准。
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