胃癌中P-gp及LRP表达及临床意义

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1、胃癌中P-gp及LRP表达及临床意义【关键词】,,p-糖蛋白；，，肺耐药蛋白摘要：目的：探讨P-糖蛋白(P-gp)和肺耐药蛋白(LRP)在胃癌中的表达及其临床意义。方法：应用免疫组化SABC法检测P-gp和LRP在80例胃癌组织和20例正常胃粘膜组织中的表达，探讨胃癌组织学类型、肿瘤浸润深度及有无淋巴结转移对P-gp和LRP表达的影响。结果:P-gp和LRP在胃癌组织中的阳性表达率高于正常胃粘膜组织(P<；0.05)；在高中分化腺癌中的表达显著髙于低分化腺癌(P<；0.05)；在浸润粘膜及粘膜下层组、肌层组、浆膜及浆膜外组表达率无显著差别(P>0.05)；在

2、有淋巴结转移组P-gp>LRP表达率显著高于无淋巴结转移组(P<0.05)o结论:P-gp.LRP在胃癌原发性多药耐药中起重要作用，其表达与组织学类型、有无淋巴结转移有关而与肿瘤浸润深度无关，联合检测P-gp.LRP对于胃癌判断预后、制定化疗方案有一定的指导意义。关键词：胃癌；P-糖蛋白；肺耐药蛋白ClinicalSignificanceandExpressionofP~gpandLRPinGastricCarcinomaAbstract：Objective：Tostudytheclinicalsignificanceandexpressionofglutathio

3、ne-s-trarmsfe:rase(P-gp)andlungresistanceprotein(LRP)ingastriccarcinomatissue・Method：TheexpressionofP-gpandLRPin80casesofgastriccarcinomaand20casesofnormalstomachtissueswasdetectedbySABCimmunohistochemicaltechnique,itscorrelationwithclinicalpathologiccharacteristicofgastriccarcinoma,in

4、cludinghistologicaltype,invasiondegreeandlymphnodemetastasis,wasexplored・ResuIt：ThepositiveexpressionratesofP-gpandLRPingastriccarcinomawereallhigherthanthoseinnormalstomachtissues(P<；0.05).TheexpressionratesofP-gpandLRPinwell-moderateddifferentiationadenocarcinomaweresignificantlyhi

5、gherthanthoseinpoordifferentiationadenocarcinoma(P<；0.05)・TherewasnosignificantdifferentiationbetweentheexpressionratesofP~gpandLRPinthethreegroupsinvadingmucomaandsubmocuma,invadingmusculairsandinvadingserosaandbeyondserosa(P>；0.05)・TheexpressionratesofP-gpandLRPinlymphmetastasisw

6、eresignificantlyhigherthanthoseinwithoutlymphnodemetastasis(P<；0.05)・Conclusion：P-gpandLRPplayanimportantrolesintheprimaryMDRofgastriecarcinoma.Theexpressionofthemisassociatedwithhistologicaltypeandlymphnodemetaaastasis,whilenotassociatedwithinvasedlayer.ThedeterminationofP-gpandLRPm

7、aybeusefulfortheestimatationofprognosisandtheestablishmentofchemicaltherapyregimeningastriecarcinoma.Keywords:Gastriecarcinoma；P-glycopropein(P-gp)；Lungresistanceprotein(LRP)胃癌是最常见的消化道恶性肿瘤，化学治疗在胃癌的综合治疗中占有重要地位，而导致化疗失败最重要原因是肿瘤细胞对抗癌药物的耐药，其中多药耐药(multidrugresistance,MDR)机制是研究的重点［1〜4］。肺耐药蛋