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1、肾结石患者体内丛生蛋白和炎症指标表达水平的临床研究彭泳涵仏，刘敏3,施晓磊1,陈锐'，李凌1,高小峰1,周铁1(1.第二军医大学附属长海医院泌尿外科，上海200433)[摘要]目的：研究肾结石患者体内丛生蛋白表达及炎症反应水平。方法：收集上海长海医院泌尿外科2015年7月〜9月间住院肾结石成人患者及体检中心健康体检成人的临床资料及血尿标本，并分为结石组和对照组，采用酶联免疫吸附试验检测两组人群血液和尿液中丛生蛋白水平，以及血液中炎症反应指标并进行対比分析。结果：结石组纳入47例，中位年龄43.00(33.50
2、-50)岁;对照组纳入56例，中位年龄3&50(32.50-53.00)岁，两组间年龄和性别差异无统讣学意义(C0.05)。结石组血液丛生蛋白水平低于对照组[156.85(151.51-195.09)ng/mlvs.171.48(151.51-195.09)ng/ml,P<0.01],两组间尿液丛牛蛋白水平差异无统计学意义[52.76(42.66-57.37)ng/mlvs.53.37(44.40-68.07)ng/ml,P>0.05]。结石组血液白介素1卩水平高于对照组[17.92(16.26-19.18)
3、ng/Lvs.13.55(12.06-17.76)ng/L,P<0.01],结石组血液白介素6水平高于对照组[53.22(46.04-71.46)ng/Lvs.46.58(42.34-52.63)ng/L,P<0.01]o结论：肾结石患者血液丛生蛋白水平降低，炎症反应水平升高。[关键词]肾结石；炎症反应；丛生蛋白；白介素ClinicalresearchonexpressionofclusterinandinflammationbiomarkersinpatientsofnephrolithiasisPENGY
4、onghan1A,LIUMin仏,SHIXiaolei1,CHENRui1,LILing1,ZHOUTie1,GAOXiaofeng11.DepartmentofUrology,ChanghaiHospital,SecondMilitaryMedicalUniversity,Shanghai200433,ChinaAbstractObjective：Toinvestigatethelevelofclustcrinandinflammationreactioninpatientsofnephrolithiasi
5、s.Methods：Clinicalmaterials,bloodandurinesamplesofinpatientswithnephrolithiasisandhealthyadultswerecollectedfromJultoSep2015inShanghaiChanghaiHospital,andELISAtestswereconductedtodetectserumandurineclusterinlevel,aswellasseruminflammationbiomarkers,tomakeco
6、mparisonbetweenbothgroups・Results：47caseswithmedianageof43.00(33.50-50)yrsand56caseswithmedianageof38.50(32.50-53.00)yrswererecruitedinthestoneandcontrolgrouprespectively,andtherewerenostatisticallysignificantdifferencesbetweentwogroupsinageandsex(P>0.05).S
7、erumclusterinlevelwaslowerinrenalstonepatientsthanthecontrolgroup[156.85(151.51-195.09)ng/mlvs.171.48(151.51-195.09)ng/ml,PvO.Ol],whileurineclustcrinlevelhadnostatisticalsignificancecomparedwiththecontrolgroup[52.76(42.66-57.37)ng/mlvs.53.37(44.40-68.07)ng/
8、ml,P>0.05].SerumIL-1卩levelwashigherinrenalstonepatientsthanthecontrolgroup[17.92(16.26-19.18)ng/Lvs.13.55(12.06-17.76)ng/L,P<0.01],andserumIL-6levelwasalsohigherinrenalstonepatientsthanthecontrolgroup[
