il—23和pg—1水平在不同胃部疾病患者体内的临床表达意义

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1、IL—23和PG—1水平在不同胃部疾病患者体内的临床表达意义［摘要］目的分析白细胞介素-23和胃蛋白酶原-1水平在不同胃部疾病患者体内的临床表达意义，为不同胃部疾病的早期鉴别提供参考依据。方法以187例胃部疾病患者为研究对象，按其诊断结果进行分组，检测患者胃组织IL-23表达及血清IL-23、PG-1表达，分析其相关性及临床表达意义。结果CAG组病变组织IL-23水平高于CSG组，GC组病变组织IL-23水平高于CAG组(P<0.05)；CSG组织中IL-23为弱阳性表达,而CAG、GC组织中IL-23均为强阳性表达。CAG组血清IL-23水平高于CSG组,GC组血

2、清IL-23水平高于CAG组(P〈0・05)；CAG组血清PG-1水平低于CSG组，GC组血清PG-1水平低于CAG组，差异有统计学意义(P<0.05)oCSG组(r二-0.470)、CAG组(r=-0.524)>GC组(r=-0.751)患者血清IL-23与PG-1均呈负相关(P〈0・05)。结论随着胃部疾病的进展，患者病变组织及血清IL-23水平逐渐升高，血清PG-1水平逐渐降低，根据患者病变组织及血清IL-23变化及IL-23/PG-1比值有望提高胃癌及癌前病变的早期检出率。［关键词］白细胞介素-23；胃蛋白酶原-1；胃部疾病；胃癌;鉴别［中图分类号］R735

3、.2［文献标识码］B［文章编号］1673-9701(2016)24-0028-03DepartmentofGastroenterology,WujinPeople，sHospitalofChangzhouCityinJiangsuProvince,Changzhou213003,China[Abstract]ObjectiveToanalyzethesignificanceofclinicalexpressionofinterleukin23(IL-23)andpepsinogen1(PG-1)inthepatientswithdifferentgastricdis

4、eases,soastoprovidereferencesfortheearlyidentificotionofdifferentgastriediseases・Methods187patientswithgastriediseaseswereselectedasresearchsubjects.Accordingtotheirdiagnosticresults,thepatientswereassignedtogroups・IL-23expressionandserumIL-23andPG-1expressioninthegastrictissuesinthepa

5、tientsweretested,andtheirrelevanceandsignificanceofclinicalexpressionwereanalyzed・ResultsIL-23levelofthepathologicaltissuesintheCAGgroupwashigherthanthatintheCSGgroup,andIL-23levelofthepathologicaltissuesintheGCgroupwashigherthanthatintheCAGgroup(P<0.05)；theexpressionofIL-23intheCSGtis

6、sueswasweaklypositive,andtheexpressionofIL-23inCAGandGCtissueswasstronglypositive.SerumIL-23levelinCAGgroupwashigherthanthatintheCSGgroup,andserumIL-23levelintheGCgroupwashigherthanthatintheCAGgroup(P<0.05)；serumPG-1levelintheCAGgroupwaslowerthanthatintheCSGgroup,andserumPG~1levelinthe

7、GCgroupwaslowerthanthatintheCAGdifferenceswerestatisticallysignificantgroup.The(P<0e05)•PG-1inthepatientsinCSGgroup(r二一0.470),CAGgroup(r=-0.524)andGCgroup(r二一0.751)(P<0.05)•ConclusionWiththeprogressionofgastricdiseases,IL-23levelsinthepathologicaltissuesandseruminthepatientsaregradua