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1、肾移植术后并发恶性肿瘤11例临床分析［摘耍］日的：探讨11例肾移植术后并发恶性肿瘤的发病情况、诊断及治疗结果。方法：回顾性分析11例肾移植术后并发恶性肿瘤患者的临床资料，对肿瘤的发生情况、诊断和治疗情况进行总结。310例患者中有11例(35・5%°)患者发生恶性肿瘤。其中，泌尿系肿瘤7例，淋巴瘤2例，宫颈癌1例，肝癌1例，除1例肝癌外其余10例均经病理确认，泌尿系统肿瘤中单发输尿管癌3例，单发膀胱癌1例，输尿管膀胱癌并发2例，另有1例为多器官性肿瘤，其肾移植术后36个月发生单侧输尿管癌,术后46个月发生单侧肾脏肉瘤样癌，术后60个月再发膀胱癌，并于膀
2、胱癌术后15个月复发，随后出现肝脏转移。11例患者发生肿瘤的时间在肾移植术后6-108个月，平均53.5个月。患者采用以手术为主的治疗，个别配合以放化疗，免疫抑制剂作适当调整。结果：2例淋巴瘤、1例肝癌及1例输尿管并膀胱癌患者1年内死亡，1例多器官性肿瘤术后笫8年因肿瘤远处转移而放弃治疗，其余患者随访至今未出现肿瘤复发或转移。结论：肾移植术后恶性肿瘤发生率明显高于普通人，尿路上皮肿瘤较多见，治疗以手术为主并行综合治疗。［关键词］肾移植；肿瘤；恶性；临床分析［中图分类号］R617［文献标识码］A［文章编号］1674-4721(2012)01(b)-02
3、2-03ClinicalanalysisofmalignanttumorsafterkidneytransplantationCAOWenjunl,2,LTUZhizhong2,LIJianxin21.GraduateSchoolofInnerMongoliaMedicalCollege,Hohhot010059,China;2.TheThirdAffiliatedHospitalofInnerMongollaMedicalCollege(CladSteelHospital),Baotou014010,China[Abstract]Objective
4、:Toanalyzetheoccurronco,diagnosisandoutcomesof11casesofmalignanttumorsfollowingkidneytransplantation.Methods:Retrospectivelyanalyzedtheclinicaldatumof11casesofmalignanttumorsfollowingkidneytransplantationandsummarizedtheoccurrenee,diagnosisandtherapy・Among310casesrenalallograft
5、recipients,11patients(35.5%o)werediagnosedwithmalignancies,ineluding7casesinurologicalsystem,2casesweremalignantlymphoma,1casewithcervicalcancer,1casewithhepaticcancer.10casesweresubstantiatedbythepathologybesides1casehepaticcancer.Amongtheurologiccancers,3caseswerecancersofure
6、tersingly,1casewasbladdercancersingly,2caseswerediagnosedwithureterandbladdercancers,1casewithmultipleorgantumor,whichwasdiagnosedwithuretercancerofoneside36monthsafterkidneytransplantation,withrenalsarcomatoidcancer46monthsandwithblandercancer60monthsafterthetransplanlation.It
7、relapsed15monthsaftertheblanderoperationandhadhepaticmetastasissubsequently.Allof11caseswerediagnosedat6-108monthsafterkidneytransplantation.Surgicaloperationwasthemaintherapyforthepatients,someneededradiotherapyandchemotherapy,theimmunosuppressantwasadjustedaptly.Results:Twoca
8、seswithlymphoma,1casewithhepaticcancerand1casewithuret
