腹膜后胃肠道外间质瘤临床病理诊断

《腹膜后胃肠道外间质瘤临床病理诊断》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、腹膜后胃肠道外间质瘤临床病理诊断【关键词】超微结构【摘要】H的探讨腹膜后胃肠道外间质瘤的临床病理特征及诊断与鉴別诊断。方法通过HE、免疫组化及电镜观察腹膜后胃肠道外间质瘤2例并复习文献。结果2例腹膜后胃肠道外间质瘤患者均为男性，年龄分别29岁、35岁;肿瘤大小分别为9cmX6.5cmX5cm和35cmX30cmX22cm;肿瘤主要由梭形、上皮样细胞组成，胞质丰富，嗜酸或淡嗜酸，可见核仁。瘤细胞免疫表型:Vimentin、NSE、S・100蛋白、SMA、CD34、CD117、bcl・2均为阳性，desmin.CK和syn阴性。电镜观察显示平滑肌瘤、神经鞘瘤和神经源性分化特征的特征

2、。结论本瘤具有平滑肌瘤、神经鞘瘤和神经源性分化的肿瘤，发牛于腹膜后罕见，其组织形态应与平滑肌瘤、神经鞘瘤、炎症性肌纤维母细胞瘤等鉴别。关键词腹膜灰肿瘤间质瘤免疫组织化学超微结构vPstyle=nTEXT-INDENT:24px”align=centei>RetroperitonealextragastrointestinalstromaltumorsWangZhuocai,LaiRiquan,HuangXiaorang,etal.

3、ter>GeneralHospitalofGuangzhouCommand,Guangzhou510010.[Abstract]ObjectiveToreporttheclinicopathologiccharacteristics,diagnosisanddifferentialdiagnosisintwocasesoftheretroperitonealextragastrointestinalstromaltumors.MethodsTwocasesoftheretroperitonealextra-gastrointestinalstromaltumorswasstud

4、iedbymeansofHEstain,immunohistochemistryandultrastiucturalobservationandliteraturerewiew.ResultsTwocasesoftheretroperitonealextragastrointestinalstromaltumorsweremale.Theywere29yeai*soldand35yearsold,respective!y.Theyrangedinsizefrom9cmX6.5cmX5cmto35cmX30cmX22cm.Thetumorcellsusuallyappeareda

5、scordsorweavecomposedofspindleorepithelioidcellswithlighteosinophiliccytoplasm.Nucleoliwereclear.ImmunohistochemicalassayshowedpositiveforVimentin,NSE,S-lOOproiein,SMA,CD34,bcl-2andCD117,butdesmin,CKandsynwerenegative.Thecharacteristicultrastructuralfeaturesshoweddifferentiationofleiomyoma,s

6、chwannomaandneurogenictumors.ConclusionTheretroperitonealextragastrointestinalstromaltumorwasaspecializedformofthegastrointestinalstromaltumorswithleiomyoma,schwannomaandneurogenictumors.ltoccuredrarelyinretroperitoneun.Differentialdiagnosticconsiderationsofretroperitonealextragastrointestin

7、alstromaltumorsshouldincludesmoothmuscletumor,neurilemmomaandinflamma-torymyofibroblastoma.Keywordsretroperitonealtumorstromaltumorimmunohistrochemistryultrastiucture胃肠道间质瘤(Gastrointestinalstromaltumors,GIST)是不成熟梭形细胞或上皮样细胞异彳f增殖形成肿瘤，常发生于胃肠道，腹膜厉较罕见;病