资源描述：
《9欧立停与佐米曲坦治疗偏头痛的交叉研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、9.欧立停与佐米曲坦治疗偏头痛的交叉研究对比利扎曲坦(Rizatriptan)10mg和佐米曲坦(Zolmitriptan)2.5mg的偏头痛急性治疗JPascual,PVega,II~CDiener,CAllen,FVrijens,KPatel和利扎曲坦-佐米曲坦研究组*UniversityHospitalMarquesdeVaideci1la,Santander,S疼痛，2HospitaiSanJose,SantaFedeBogota,Colombia,3NeurologischeUniver
2、sitatsklinikEssen，Essen,Germany,4Merck&Co.Inc.,WhitehouseStation,NJ,USA,internationalInstituteforDrugDevelopment,Brussels,Belgium■蔘1j木次试验的研究人员列出如＞tEPJArnoldus,PLMdeKort.EAycardi.JFHernandez,EBancalari,JTapia,JNBerendes,KKeizer,NBlegvad,SBoesHansen,GBo
3、vim,KHagertJACarpay,KCHLyppens,MCarvajal.HAllan,EGMCouturier,GCrawford,LCunhaTLDeSousa,CDahlof,PLinton-DahlotUDickman%HCDiene匚CUrban,ADowson,JJMDriesen,WFvanOudenaarden,PEsperanca,HEvenblij,GdeJong.SEvers,AFrese,AFazekas.AJooriBirkas,JDFernandezOrtega
4、,VMoreno.HGobeLAHeinze.FGomez-Aranda.RAlberca.MGross,JHernandezGallego.MCPerezVieite.WAFHoefnagels,OEHolm-Thomsen:JBMtenHolter,JHMvanGasteren.JPJansen,SSaschowatIJelencsik,GBozsik,JJimenez・Gil：FJohansson.AAgren-Wilsson.GJohansson,CKaplan.KjaersgaardPe
5、dersen,PJJKoehler.BKukowski.GLadurnertGLuthringshauseJMLaine乙JParra,CLampl,DKlingler,JMatiasGuiu,MAsensio-Asensio,MMiddle,FOMiiller,CMuhr?JURNiewold,KtenNapel.TNolte.AParajeles,RSamchez,JAParejaGrande,JPascual,FPayer.PKapeller,JCPerez-Garcia,JPrat,JAM
6、artinez-Matos・PJMRaedts.JJMHagemans,JRainer.GSixt.MRibbat,IRodriguez-Leyva,GStaaf,JSchiemann,MlVergara,PSchmidtSorensemGSchn吕berth,AVacariu,TSevillaMantecon,JABurgueraHernandez,BSteinberg,BStandnes,TJTacke.LVecsei.JCBVerheij,AUngurean,PVega,IValencia.
7、PWessely.CWober・CephalalgiaPascualJ,Vega.P,DienerII-C,AllenC,VrijensF,PatelK和利扎曲坦-佐米曲坦研究组。对比利扎曲坦10吨和佐米曲坦2.5的偏头痛急性治疗。《头痛》(2000);20:455-461。伦敦。ISSN0333-1024。在一项旨在对比利扎曲JJKMAXALT®)和佐米曲坦(ZOMTG®)疗效和耐受性的随机、双盲、双模拟、分层(Z前使用利扎曲坦和/或佐米曲坦)、安慰剂对照试验中，766名患者接受了对单纯偏头痛发
8、作的治疗。服药60分钟内，利扎曲坦能够提供较佐米曲坦更短时间实现疼痛消失(风险比为1.26,P=0.075)o与服用佐米曲坦的患者相比，更多服川利扎曲坦的患者于用药2小时内出现疼痛消失(43.2%：35.6%,P=0.041),而两种药物的2小时头痛缓解率是和似的(70.5%：66.8%)o用药2小时，较少服用利扎曲坦的患者出现畏光(35.6%：43.5%,P=0.029)和恶心(25.2%:32.5%,P=0.046)的症状;并且与佐米曲坦相比,更多服用利扎曲坦的患者存在功能正常
