多潘立酮联合复方消化酶治疗功能性消化不良84例

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1、临床经验CLINICALPRACTICE多潘立酮联合复方消化酶治疗功能性消化不良84例郑丹，夏冰，施先艳，宋敏，吴杰，王萍，张姮■管呂资斜功能性消化不良发病率较高，是临床上常见的消化系统疾病，常规采用的单纯促动力治疗效果并不佳.功能性消化不良有不同的病理生理机制，不同症状与不同病理生理机制有关，而非某种病理生理机制能解释所有症状.针对不同机制的多药联合应用治疗功能性消化不良从理论上分析应具有更好的疗效.本文尝试多潘立酮联合复方消化酶治疗，取得了一定效果.郑丹，夏冰，施先艳，武.汉大学中南医院消化内科湖北省武汉市430071郑丹，宋敏，吴杰，王萍，张姮

2、，武汉市中心医院消化內科湖北省武汉市430014作者贡献分布：此课题由郑丹，夏冰及施先艳设L研究过程由郑丹.宋敏，吴杰，王萍及张姮共同完成；夏冰.施先艳，吴杰及王萍对此研究提供指导、技术支持；数据分析、论文写作由郑丹完成通讯屉者：夏冰.430071,湖北省武汉币武昌区武汉大学中南医院消化内科.bingxia2004@yahoo.com.cn电话：027-67812999传真：027-67812892收稿日朋:2008-09-15修回日朋:2008-12-17接受日朋：2008-12-22在线出版日朋：2009-01-28Combinedtherapy

3、ofdomperidoneandcompounddigestiveenzymesforfunctionaldyspepsia:ananalysisof84casesDanZheng,BingXia,Xian-YanShi,MinSong,JieWu,PingWang,HengZhangpeuticefficacyandsideeffectswerecomparedbetweenthetwogroupsbychisquaretest.RESULTS:Thegeneraltherapeuticefficacyintheexperimentalgroup

4、wassuperiortothecontrols(85.7%vs61.9%,P<0.05).Thesymptomsofupperabdominalpain,abdominaldistention,earlysatietyandstomachburninthepatientsintheexperimentalgroupweremoreimprovedthaninthecontrolgroup・Theexperimentalgrouphadshownshorteronsettimethanthecontrols・Nosevereside-effects

5、werefoundinthebothgroups.CONCLUSION:Combinedtherapyofdom-peridoneandcompounddigestiveenzymescanmoresignificantlyimprovegeneralefficacyandsymptomsinpatientswithfunctionaldyspepsiathansingleuseofmotilitymedicinedomperi-done.DanZheng,BingXia,XiarvYanShi,DepartmentofGastroenterolo

6、gy,WuhanUniversityZhongnanHospital,Wuhan430071,HubeiProvince,ChinaDanZheng,MinSong,JieWu,PingWang,HengZhang,DepartmentofGastroenterology,theCentralHospitalofWuhan,Wuhan430014,HubeiProvince,ChinaCorrespondenceto：BingXia,DepartmentofGastroenterology,WuhanUniversityZhongnanHosp

7、ital,Wuhan430071,HubeiProvince,China,bingxia2004@yahoo.com.cnReceived:2008-09-15Revised:2008-12Accepted:2008-12-22Publishedonline:2009-01-28KeyWords:Functionaldyspepsia;Domperidone;CompounddigestiveenzymesZhengD,XiaBzShiXYZSongMzWuJ,WangPzZhangH・Combinedtherapyofdomperidoneand

8、compounddigestiveenzymesforfunctionaldyspepsia:ananaly