乳腺癌组织中微淋巴管分布及密度临床病理意义

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1、乳腺癌组织中微淋巴管分布及密度临床病理意义作者：张宇宋吉宁周为黎卫平马岚【摘要】目的探讨乳腺癌组织中微淋巴管分布、密度及其与相关临床病理因素之间的关系，分析乳腺癌淋巴结转移的可能机制。方法应用免疫组化SABC法检测50例乳腺癌及其相应癌旁正常乳腺组织中D2-40的表达，并分别计数其微淋巴管密度(microlymphaticdensity,MLD)。结果乳腺癌组织中的MLD明显高于癌旁正常组织(P<；0.01),且肿瘤不同区域中MLD有所差异，肿瘤边缘区MLD均值显著高于癌旁正常组织及肿瘤中心区均值(P<；0.01)；肿瘤中心区MLD与正常组织MLD无显著性差异(P>；

2、0.05)；肿瘤边缘区MLD与乳腺癌的临床分期、淋巴结转移状态相关(P<；0.01),与年龄、肿瘤大小、组织分型及雌、孕激素受体状态无关(P>；0.05)o结论1)乳腺癌组织中存在淋巴管，且分布存在异质性，淋巴管主要分布于肿瘤边缘区，肿瘤边缘区MLD与淋巴结转移、临床分期状态相关，其MLD的增加可能与乳腺癌的侵袭及转移相关；2)乳腺癌组织中的MLD检测可作为评估乳腺癌淋巴结转移状况的一项辅助指标，为判断乳腺癌患者预后及确定临床治疗方案提供实验和理论依据。【关键词】乳腺癌D2-40MLD淋巴结转移免疫组织化学AbstractObjectiveToinvestigatethe

3、characteristicsofdistributionanddensityoflymphaticvesselandthecorrelationwithitsclinicopathologicalfactorsinbreastcancerandanalysethepossiblemechanismoflymphnodemetastasisinbreastcarcinoma.MethodsMakinguseofimmunohistochemistrytoresearchtheexpressionofD2-40in50casesofbreastcarcinomaandthenorm

4、altissuesnearthetumorborderline,whichmicrolymphaticdensitywascounted・ResultsTheMLDinbreastcarcinomawassignificanthigherthanthatinthenormaltissueadjacentcarcinoma(P<；0.01)anditwasnotthesameindifferentaerasofcarcinoma.TheMLDintumorborderlinewashigherthanthatinthenormaltissuesandtumorcentertis

5、sues(P&It；0.0l)andTherewasnocorrelationinthetumorcenterandthenormaltissue(P>；0.05).TheMLDintheborderlinehadpositiverelationtotheclinicalstage,andlymphnodemetastasis(P&It；0.01),butithadnosignificantdifferencefromage,tumordiameter,histologictypes,progestogerandestrogenreceptorcondition(P>；0

6、.05)・Conclusions1.Thelymphaticvesselappearsinthebreastcarcinoma.Itmainlydistributesinthetumorborderline・TheMLDinthetumorborderlinehascorrelationwithclinicalstage,lymphnodemetastasis・TheincreaseofMLDmayberelatedtotheinvasionandmetastasisofbreastcarcinomainthetumorborderline・2.ThedetectionofMLD

7、inthetissueofbreastcarcinomacanbeaimportontaffiliatedmarkerstoevaluatethelymphnodemetastasis・Italsocanmeasuretheprognosisofbreastcarcinomaandprovideexperimentalandtheoreticalfoundationtoconfirmtheclinicaltreatmentmethods.KeywordsBreastcarcino