乳腺肿块微血管密度及血氧近红外光参数实验探究

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1、乳腺肿块微血管密度及血氧近红外光参数实验探究作者：黄烽，陈登峰，袁璐，刘艳，刘华，张柳，孔蹌，王虹【摘要】目的从组织微血管分布密度初探乳腺肿块血氧近红外光参数的可靠性。方法用近红外光TBO—I型双波长乳腺肿瘤检测仪，对检测的181例乳腺肿块进行近红外光血氧参数分类和病理切片检查明确肿块性质，并对其中20例恶性肿块和20例良性肿块进行免疫组织化学SP法检测乳腺肿块微血管密度，运用医学统计学方法分析近红外光血氧参数与微血管密度的相关性。结果(1)28例高血乳腺肿块微血管密度值和血含量值分别为24.56±8.110和1.891±0.850,

2、12例低血乳腺肿块微血管密度值和血含量值分别为17.98±8.729和0.698±0.283,两者比较存在显著性差异(P<；0.05)；(2)40例乳腺肿块的微血管密度值与近红外光血含量值直线相关系数分别为r=0.4208(P<；0.05)o结论乳腺良、恶性肿块局部微血管密度与其血含量近红外检测参数存在相关性，说明了近红外光血含量检测参数作为诊断乳腺癌标准的可靠性。【关键词】乳腺肿块;微血管密度；血氧近红外光参数ExperimentalStudyonNearinfraredParametersofBloodOxygenandM

3、icrovesselDensityofMammaryGlandPhymaAbstract：ObjectiveTodetectthereliabilityofnearinfraredparametersofbloodoxygenofmammaryglandphymafromthemicrovesseldensityoftumor・Methods181casesofmammaryglandprymawhohadaccepttheexaminationofthenearinfraredTBOIdualwavelengthmammarygla

4、ndphymadedecforwereclassifiedbynearinfraredparametersofbloodoxygen,andwereperformedthepathologicexminationtoascertainwhethertumorisbenignormalignant.Outofthesecases,intratumormicrovesseldensifyof20casesofmalignantphymaand20casesofbenignphymawereconfirmbyspimmunohistoche

5、micalmethods,thentherelationamongnearinfraredparametersandmicrovesseldensitywereanalyzedbymedicalstatistics.ResuIts(1)themicrovesseldensityandbloodconcentrationof28casesofthe”highbood”tumorwas24.56±8.110,1.891±0.850respctively.Themicrovesseldensityandbloodconcentrationo

6、f12casesofthe"lowblood"was17.98±8.729,0.698+0.283respectively.Thereissignificantdifferencebetweenthe"highblood”tumorand"lowbloodtumor・(P<；0・05)・(2)Theintratumormicrovesseldensityandbloodconcertrationislinearlycorrelatedrespectively,thelinearcorrelationcoefficientr二0.4

7、208(P<；0.05)in40casesofmammaryglandphyma・ConelusionTheintratumormicrovesseldensityofbenignormalignantmammaryglandphymaandbloodconcentrationislinearlycorrelated.Bloodconcerntration(oneofnearinfraredparameters)isreliabletobeusedasdignosiscriterionofmalignantmammarygland

8、phyma・Keywords:Mammaryglandphyma；Microvesseldensity；Nearinfraredparametersofbloodoxygen0引言近红外光无创伤检测组织血氧饱和度的技术在