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1、两种方法治疗胃溃疡的临床研究［摘耍］冃的:观察两种方法治疗胃溃疡对其血清胃泌素及胃黏膜血管内皮生长因子水平的影响。方法：经胃镜和活检证实的活动性胃溃疡患者80例，随机分为中西医结合组(治疗组)40例和西医组(对照组)40例，观察两组患者治疗前后胃泌素、胃黏膜血管内皮牛长因子水平的变化。结果：治疗组治疗后胃泌素为(30.2±9.9)pmol/L,明显低于治疗前的(36.0±11.2)pmol/L(t=2.345,P<0.05)；血管内皮生长因子为(16.2+5.6)%,明显高于治疗前的(6.2土2.3)%(t=2・415,P<0.05)；对照组治疗后胃泌素为(29.3±8.
2、9)pmol/L,明显低于治疗前的(35.8±10.8)pmol/L(t=2.245,P<0.05):血管内皮生长因子为(13.8±4.3)%,明显高于治疗前的(6.6土2.4)%(t=2.325,P<0.05)；治疗组治愈率为90.0%,明显高于对照组的65.0%(x2=3.98,P<0.05)0结论：中西医结合可以提高溃疡愈合质屋，可能打血胃泌素水平、血管内皮生长因了表达有关。［关键词］胃溃疡；胃泌索；血管内皮生长因子［中图分类号］R573.1［文献标识码］A［文章编号］1673-7210(2009)02(b)-021-02Theclinicalstudyinpati
3、entswithgastriculcerbytwotreatmentmethodsHUANGXing-ail,ZHANGYuan-fangl,GULi-hual,ZHAOWen-li2(1・DepartmentofInternalMedicine,XingxuHospital,HuiyangCity,Huiyang516200,China;2.PathologyDepartment,HuizhouCcntralHospital,Huizhou516001,China)［Abstract］Objective:Toobservethelevelsofbloodgastrina
4、ndvascularendothelialgrowthfactor(VEGF)inpatientswithgastriculcer.Methods:80caseswithgastriculcerweredividedintoChineseandWesternmedicinegroup(treatmentgroup)andWesternmedicinegroup(controlgroup),eachgrouphad40cases.ObservedthelevelsofgastrinandVEGFbeforeandaftertreatmenl・Results:Intreatm
5、entgroup,thelevelofgastrinwas(30.2±9.9)pmol/Laftertreatment,whichwassignificantlylowerthan(36.0±11.2)pmol/Lbeforetreatment(t=2.345,P<0.05);thelevelofVEGFwas(16.2±5.6)%,whichwassignificantlyhigherthan(6.2±2.3)%beforetreatment(t=2・415,P〈0・05).Incontrolgroup,thelevelofgastrinaftertreatmentwa
6、s(29.3土&9)pmol/L,whichwassignificantlylowerthan(35.8±10.8)pmol/Lbeforetreatment(t=2.245,P<0.05);thelevelofVEGFwas(13.8±4.3)%,whichwassignificantlyhigherthan(6.6±2.4)%(t=2.325,P<0.05)beforetreatment.Thecureratewas90.0%intreatmentgroup,whichwassignificantlyhigherthan65.0%incontrolgroup(x2=3
7、.98,P<0.05).Conclusion:ChineseandWesternmedicinecanimprovethequaIityofulcerhealing,whichisrelatedwithserumgastrin,VEGFlevels・［Keywords］Gastriculcer;Gastrin;Vascularendothelialgrowthfactor消化性溃疡(PU)主耍是指发生于胃和十二指肠的慢性溃疡，具有周期性发病、容易反复等特点。属于屮医"胃脱痛”、"痞证”、“反胃”、“吐酸”的范畴。木文采用屮西医
