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1、Bioinformatics1HowtoreachmeName:陶士珩Tel:13572899451，87091060Email:shihengt@nwsuaf.edu.cnAssessmentandGradingAssessment:TestGrading:Quizs(30%)Finalexam(70%)3Resources4T.CharlieHodgman,AndrewFrench,DavidR.Westhead.Instantnotesinbioinformatics,secondedition.Alsoreco
2、mmended:JonathanPevsner.BioinformaticsandFunctionalGenomics中译本,2006.DavidWMount.Bioinformatics:SequenceandGenomeAnalysis,2004.Secondedition.5Goals6Introducefundamentalproblems,concepts,methods,andapplicationsinBioinformaticsEmphasizeboththemethodsandthepractical
3、useofbioinformaticstoolsanddatabases.LectureSyllabus7OverviewofBioinformaticsProbabilityandStatisticsDatabaseandDatabaseSearchGenomesandOtherSequencesTranscriptomicsandProteomicsChapter1 Overviewofbioinformatics8Outline9WhatisBioinformatics?Whyusebioinformatics?
4、AimsofBioinformaticsWhyBioinformaticsbecomesHotField?Maintopicsinbioinformatics.GetaprimaryimpressionofthebioinformaticsfieldanditsmaintopicsGoalWhatisbioinformatics?AnalysisSequenceStructureFunctionEvolutionPathwayInteractionMutationExpression10ExperimentsHypot
5、hesisDataResultsWhatisbioinformatics?11NIHdefinitionsBioinformatics:Research,development,orapplicationofcomputationaltoolsandapproachesforexpandingtheuseofbiological,medical,behavioralorhealthdata,includingthosetoacquire,store,organize,archive,analyze,orvisualiz
6、esuchdata.Todiscovernewbiologicalinsightsusingcomputerandbiology.Otherrelateddisciplines12ComputationalBiology:Thedevelopmentandapplicationofdata-analyticalandtheoreticalmethods,mathematicalmodelingandcomputationalsimulationtechniquestothestudyofbiological,behav
7、ioral,andsocialsystems.Chemoinformatics:Studyandanalysisofchemicalinformation.Otherrelateddisciplines13Medicalinformatics:Study,inventionandimplementationofstructuresandalgorithmstoimprovecommunication,understandingandmanagementofmedicalinformation.HistoryofBioi
8、nformatics1415MaxFerdinandPerutzJohnCowderyKendrewFrancisCrickJamesDeweyWatsonLinusPaulingFrederickSangerMajoreventsin bioinformaticshistory161962Pauling'stheoryofmol
