２型糖尿病合并高血压患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系

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1、2型糖尿病合并高血压患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系刘起琛1刘长山2刘素华1刘晓娜1梁磊3李慧明3柳林2通信作者山东潍坊滨海经济技术开发区人民医院1内分泌科3超声科山东262737;2潍坊市人民医院内分泌科山东潍坊261041【摘要】目的探讨2型糖尿病(T2DM)合并高血压患者血浆同型半胱氨酸(Hey)与颈动脉内膜一屮层厚度(IMT)的关系.方法回顾性分析在我院住院的180例T2DM患者临床资料，按伴有高血压与否，分为单纯糖尿病组(DM组)86例、高血压合并T2DM组(HBP+DM组)94

2、例，单纯高血压病组(HBP组)83例，另选择健康体检者85例为健康对照组•均测定HbAlc、TC、TG、HDL、LDL、FBG等指标及血Hey,彩色多普勒超声仪行颈动脉内膜中层厚度检查，进行比较分析•结果DM组、HBP组、HBP+DM组血浆Hey水平明显高于正常对照组(P<0・01).HBP+DM组血浆Hey水平均高于HBP组及DM组(PV0・01).HBP+DM组IMT均高于DM组、HBP组及对照组(P<0.01)•结论T2DM合并高血压患者jllLHcy水平与颈动脉内膜一中层厚度程度密切相关.【关

3、键词】糖尿病,2型;高血压;同型半胱氨酸;颈动脉内屮膜厚度；Relationshipbetweentheplasmlevelofhomocysteineandcaroticintmial—medialthicknessintype2diabetescomplicatedwithhypertensionLiuQichen丄iuChangsGhan丄iuSuhua丄iuXiaona,LiangLei丄iHuiming丄iuLin.BinhaiEconomicdevelopmentzonepeople&rs

4、quo;shospital,Weifang,Shandong,262737.CorreGspondingauthor:LiuLinEmail:liulin_sd@sina.com[Abstract]ObjectiveTodiscusstherelationshipbetweentheplasmlevelofhornocysteine(Hcy)andcaroticintmial—medialthickness(IMT)intype2diaGbetes(T2DM)complicatedwithhypert

5、ension.MethodsAretrospectiveanalysisoftheclinicaldataof180casesofpatientswithT2DMinourhospital’accordGingtowhetherornocomplicatedhypertension,patientsweredividedintoDMgroup(DM)86cases,hypertensioncomplicatedwithT2DM(HBP+DMgroup)94cases.85ageandsex—match

6、edhealthysubjectsselectedascontrolgroupandselecthypertensiongroup(HBPgroup)83cases.DetectedtheHbA1c/TC/TG’HDL丄DL,FBGandplasmaHcyoffourgroups・Inspectedcarotidintima—mediathicknessbyColorDopplerultrasoundandanalyzedtheresults・ResultsComparedthecontrolgrou

7、p,plasmaHcylevelsweresignificantlyhigherinDIZlgroup,HBPgroupandHBP+DMgroup(P<0.01);thelevelsofplasmaHcyofHBP+DMgroupwerehigherthanthato伯BPandDMgroup(P<0.01),thelMTo伯BP+DMgroupwerehigherthanDMgroup’HBPgroupandcontrolgroup(P<0.01).ConclusionTheplasmaleve

8、lofhomocysteinewascloselyrelatedtocaroticintmial—medialthicknessinT2DMcomplicatedwithhyper【tKeenysiownords]diabetesmellitus,type2；hypertension;homocysteine;caroticintmial—medialthickness【中图分类号】R587.1【文献标识码】B【文章编号】1008—6315(2015)1