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1、RelatedproblemsonclinicalapplicationofplasmalipidsassayProfessorzhouxinDepartmentofLaboratoryMedicine,Zhongnanhospitalofwuhanuniversity.Dr.Sheng-kaiYan,PhDDepartmentofLaboratoryMedicine,PekingUnionMedicalCollegeHospitalAllkindsoflipidsinplasmawerecalledbloodlipidsTotalcholesterol，TC＝freecholesterol＋
2、cholesterolesterNeutralfatty—triglyceride，(TG)nonesterifiedfattyacid（freefattyacid，FFA）phospholipid,glucolipidLipidswereinsolubleinwater,theyweretransportedintheformoflipoproteinPlasmalipidsPlasmalipoproteinLDLLp(a)VLDLIDLHDLstructureoflipoproteinClinicalitemsforlipidsdetectiontotalcholesterol，TCtri
3、glyceride，TGhighdensitylipoproteincholesterol，HDL-Clowdensitylipoproteincholesterol，LDL-CapolipoproteinA1，ApoA1apolipoproteinB，ApoBlipoprotein(a)Thefirstfouritemswereroutinetest,andshouldbecarriedoutinhealthyexaminationsCinicalitemsforlipidsanalysis(2)FFACerebrosideesterceramideSphingenineSphingomye
4、linGalactode-cerebrosideGenotypeApoEgenotypeApoCIIIgenotypeApoCIIgenotypeApo(a)genotypeLDLRgenotypeVLDLRgenotypeHMGCoARgenotypeSRgenotypeCinicalitemsforlipidsanalysis(3)PreanalyticalFactorsAffectingLipidTestResultsThefollowingfactorsmaycausepreanalyticalvariationsBiologicalfactorsIndividualbiologica
5、lvariations,gender,age,andrace,etc.Life-stylefactorsdiet,obesity,smoking,stress,alcohol,andcoffeeintake,andexercise,etc.Behaviourfactors(1)DietThefoodcontainingabundantunsaturatedfattyacidcandecreasethelevelofTC,LDL-C,apoBandTG.ThefoodcontainingabundantsaturatedfattyacidcanelevateTC,LDL-C.Thefoodcon
6、tainingabundantfibercanreducethelevalofTC.ThelevelsofLDL-CandLp(a)invegetarianswerelower(37％,35％respectively)thannon-vegetarians,whileHDL-Cwerehigherthanthatof12％.Behaviourfactors(2)ObesityTG，TCandLDL-C↑HDL-C↓LostweightTG（40％）↓TC（10％）↓LDL-C（10％）↓HDL-C（10％）↑SmokingTG,LDL-CandLp(a)↑↑apoAandHDL-C↓↓HDL-
7、C↓Behaviourfactors(3)Behaviourfactors(4)AlcoholabuseHDL-C,apoAⅠ,apoAⅡ↑（1.2oz/dor34g/d）PrimryhypertriglyceridemiawithmilddrinkingcanleadtothelevelofTGincreasedfurther.AlcoholhasdifferenteffectsonLp(a)f
