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1、有机化学的研究进展122322黄培强唐功利赵刚岳建民吴金波田伟生123(厦门大学化学学院；中国科学院上海有机化学研究所；中国科学院上海药物研究所)AdvanceinOrganicChemistry1223HuangPeiqiang,TangGongli,ZhaoGang,YueJianmin,22WuJinbo,TianWeisheng12(XiamenUniversity,ShangInstituteofOrganicChemistry,CAS,3ShanghaiInstituteofMetriaMedica)In2008，theor
2、ganicchemistryinChinahavemadegreatprogress.Thisannualreportpresentedsomemainresearchachievementsrelatedtoorganicreaction,organicsyntheticchemistry,naturalproductchemistry,elementalorganicchemistryandbio-syntheticchemistrywhichmadebychemistsinChinamainland.Theannualcollec
3、ted19metallicororganicmolecularcatalyticreactionswhichhavebeenreportedininternationaljournalssuchasJACS,Angew.Chem.,andsoon.Themetalliccatalyticreactionmainlyinvolvedthepalladiumcatalyticreactionincludingallylicamination,allylicsubstitution,arolyationofaniline,alleneaddi
4、tionaswellasdominoreactionormulti-componentsreaction.Organicmolecularcatalyticreactionsrelatedtoprolinederivativescatalyticreactions.29newnaturalproductsincludedPzewalskinB,ChlorahololidesAandB,MachilaminosidesAandB,Pre-schisanartanin,PaxdaphninesAandB,DaphlongeraninesAa
5、ndB,MacropoduminesDandE,E-alstoscholarine,WalsuronoidsAandB,ChuktabularinsA∼DaswellasChloropupukeananinwhichwereisolatedbyChinesescientistsin2008willbeenpresentedinthisreport.Thesenewmoleculeswillbeveryusefulfornewdrugdiscoveryanddevelopment.Thechemicalsynthesisofsomeint
6、erestednaturalproductssuchasSalinamideA,Chororfusin,AmphidinolideY,lobatosideE,(±)-CommunesinF,(±)-Stemonamine,CrisamicinAandsoonhavebeenfinishedbyChinesechemistsandpublishedininternationaljournals.ThesynthesisofsupposedandstructuraluniqueofN,N’-dihydroporphyrinorisophlo
7、rinwith20πelectronwillbealsocollectedinthisannualreport.ThisannualreportnotonlycollectedChineseorganicchemist’sresearchachievementappearedinacademicjournalsin2008butalsocontainedsomeoneappliedinindustrialproduction.131一、引言有机化学是化学科学中的一个十分重要的二级学科。有机化学作为一门中心学科，它的发展不仅与化学学科的发
8、展直接相关，而且也不断地影响和促进着其它自然科学学科的发展。同样，有机化学作为一门实用性学科，其发展一直影响着人类社会的发展。有机化学与人类社会发展息息相关，与国民经济建设密切相连。我国有机化学事业在近年来
