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1、复方苦参注射液联合FOLFOX4方案治疗晚期胃癌疗效观察吴hi刘徳玲张雪玲刘付花［摘要］目的探讨复方苦参注射液联合FOLFOX4方案治疗晚期胃癌的临床疗效及毒副反应,。方法65例经病理确诊的晚期胃癌患者随机分为两组，治疗组34例，采用复方苦参注射液联合FOLFOX4方案化疗：草酸钳85mg/m2,静滴2h(先入)，第1天；甲酰四氢叶酸钙200mg/m2,静滴2h,第1〜3天；5-氟服卩密噪400mg/m2,快速静注，追加600mg/m2,持续静滴22h,第1〜3天。同期静脉滴注复方苦参注射液20ml,1次/d,连用
2、14天后，休息14天，28天为一个周期。对照组31例，单纯采用FOLFOX4方案化疗，草酸钳、甲酰四氧叶酸钙和5-氟腺卩密喘用法同治疗组。对两组的总反应率、毒副反应、生活质量改善率、屮位进展时间(MTTP)和中位生存期(MST)作冋顾性分析。结果治疗组与对照组的总反应率分别为58.8%(20/34)和48.4%(15/31),无显著性差异(X2=0.71,P>0.05)浣全缓解率分别为20.6%(7/34)和3.2%(1/31),有显著性差异(X?二4.53,P<0.05);试验组胃肠道反应和骨髓抑制较对照组减轻，
3、差异冇统计学意义(p<0.05)；试验组化疗后KPS评分明显高于对照组(pvO.Ol)。生活质量改善率分别为82.6%和60.0%,有显著性差异(X2=4.78,R0.05)。MTTP及MST差异亦具有显著性。结论复方苦参注射液联合FOLFOX4方案治疗晚期胃癌的疗效较好，患者不良反应轻，具有改善患者生活质量的作用。［主题词］复方苦参注射液；FOLFOX4方案；联合；晚期胃癌TherapeuticEffectsofcompoundKusheninjectionplusingFOLFOX4RegimenonAdvan
4、cedGastricCancerWUTian,LIUDe-ling,ZHANGXue-ling.LIUFu-hua.DepartmentofOncology,TheCentralHospitalofShanxianCounty,Heze,274300［Abstract］ObjectivesToexploretheefficacyandtoxicityofcompoundKusheninjectionplusingFOLFOX4Regimeninthetreatmentonpatientswithadvancedga
5、striccancer(AGC).MethodsSixty-fivepatientswithAGCweredividedintotwogroupsrandomly,amongwhich34cases(treatmentgroup)weretreatedbycompoundKusheninjectionplusingFOLFOX4Regimen:OXA85mg/rrriv2h(givenfirst)d］,LV200mg/m"iv2hfollowedby5-Fu400mg/mivand5-Fu600mg/miv22h山
6、〜3weregiven,andcompoundKushcninjection20ml/divdriplastfor14dwasgiveninthesametime.andevery28das1cycle,and31cases(controlgroup)byFOLFOX4regimenonly.ThedosesandmethodsofOXA,LVand5-Fuweresameasthetreatmentgroup-Theoverallrateofresponse>toxicity>improvementofQOLan
7、dprogress!onfreesurvivorforthetworegimenswereanalysedretrospectivcly.ResultsTheclinicalcharacteristicsofthetwogroupsweresimilar(/^O.05).Allpatientscouldbeevaluated.TheORRoftreatmentgroupandcontrolgroupwas58.8%(20/34)and48.4%(15/31)respectively,Therewasnosignif
8、icantdifferenceUM).71,Q0・05);TheCRwas20.6%(7/34)and3.2%(1/31)respcctivcly,showingasignificantdifference(X2=4.78,P〈0.05)•Themyelosuppession、neuro-sensorytoxicityandnausea/vomitingin
