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1、MeaslesXieminDepartmentofPediatrics,XiangyaHospitalwww.themegallery.comIntroductionXiangyaHospitalInthe9thcentury,thefirstscientificdescriptionbyPersianIn1529,ameaslesoutbreakinCubaIn1531,measleskilledhalfthepopulationofHondurasIn1875,measleskilledover40,000FijiansDuringthe
2、1850s,measleskilledafifthofHawaii’speopleInthe19thcentury,measlesdecimatedtheAndamaneseIn1954,measlesviruswasisolatedfromaUSAboyIn1963,measlesvaccinesbecameavailableIn1968,animprovedmeaslesvaccinebecameavailablewww.themegallery.comMeaslesdeathXiangyaHospitalGlobally,in1999,
3、about873,000deathsAfrica,in1999,about506,000deathsIndia，about100,000childrendieasaresultofmeasleseachyearIn2000,1.7millionvaccine-preventablechildhooddeathsoccurred,ofwhich777,000wereattributedtomeasles.Globally,in2004,about454,000measlesdeaths撒哈拉以南非洲216000[216000-279000]南亚
4、202000[145000-264000]东亚和太平洋32000[21000-47000]中东和北非4000[2000-5000]欧洲和中亚<1000[-]拉丁美洲和加勒比<1000[-]高收入国家<1000[-]总计454000[329000-596000]Worldwidemeaslesremainsthefifthleadingcauseofmortalityamongchildrenaged<5yearswww.themegallery.comRecentoutbreaksXiangyaHospitalOnFebruary19,200
5、9,505measlescaseswerereportedintheNorthofVietnamApproximately1000measlescaseswerereportedinIsraelbetweenAugust2007andMay2008In2007,alargemeaslesoutbreakinJapanIn2008,1,217caseswerediagnosedintheUnitedKingdomwww.themegallery.comMeaslesXiangyaHospitalMeaslesisacommomandhighly
6、contagiousdiseasewithhighmorbidityandmortalityItiscausedbyinfectionwithmeaslesvirusandcharacterisedbyfever,cough,coryza,conjunctivitis,Koplik’sspotanderythematousmaculopapularwww.themegallery.comMeaslesvirusXiangyaHospitalMemberofthefamilyofParamyxovirusesssRNAenvelopedviru
7、s,aseparategenus,themorbillivirusoneserotypeonlyandthereareverylittledifferencesbetweendifferentisolateswww.themegallery.com临床症状基本病变主要见于皮肤淋巴组织呼吸道肠道粘膜病变部位单核细胞浸润增生形成多核巨细胞局部上皮细胞淋巴组织中繁殖XiangyaHospitalPathogenesis麻疹病毒单核巨噬细胞鼻咽病毒血症Syncytialformationcausedbymeaslesvirusincellcultur
8、ewww.themegallery.comsusceptiblepopulationwithoutimmunityXiangyaHospitalEpidemiolo
