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...acoustic 低强度连续超声波对纳米液滴影响

...acoustic 低强度连续超声波对纳米液滴影响

ID：43168853

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页数：13页

时间：2019-10-01

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1、EffectoflowintensityCWultrasoundonacoustic responsesofmicrobubblesgeneratedfromphase changenanodropletKenichiKawabata,ReiAsami,TakashiAzumaandShinichiroUmemuraCentralResearchLaboratory,Hitachi.Ltd.,Tokyo,JapanDept.BiomedicalEngineering,TohokuUniversitySendai,Japan生物医学工程101孙巍1011082023Abst

2、ract:Sustainingofmicrobubblesgeneratedfromaphasechangenano-droplet(PCND)wasdemonstratedbyusinglowintensityultrasoundaimingatpreciselytargetedultrasoundtherapy.WhenCWexposurewasusedforthesustainingprocedure,Thissuggeststhefundamentalsignalwasemittedfromthesustainedmicrobubblesbecausefurthe

3、rexposureof100W/cm2ultrasoundfollowingthesustainingultrasoundresultedinthegenerationoffractionalharmonics,suggestingtheinductionofcavitation,whilenoharmoniccomponentswereobservedintheabsenceofthesustainingultrasound.Itwaspossibletousepulsedultrasoundforthesustainingprocedure,whentheinterv

4、albetweeneachpulsewaswithin10ms.ThetimeconstantwasaboutthesameasthelifetimeofthemicrobubblesinducedfromthePCNDintheabsenceofthesustainingultrasound.TheobtainedresultsarepromisingforcontrollingthesensitivityoflocalsitestotherapeuticultrasoundbyusingPCNDandlowintensityultrasoundKEYWORDS：pha

5、se-changenanodropletmicrobubblecavitaionI.INTRODUCTIONII.MATERIALSANDMETHODSIII.RESULTSANDDISCUSSIONCONTENT:IntroductionMicrobubblesarewell-establishedcontrastagentsusedinultrasoundechographyandhavemostlybeenusedtovisualizevascularity.Recently,theyhavebecomepromisingtoolsforsitespecificdi

6、agnosisandtherapyincombinationwithultrasound.Eliegaraetal.firstdemonstratedtargetedcontrastimagingbyattachingligandmoleculesontothesurfaceofmicrobubblecontrastagents.Inadditiontodiagnosticpurposes,microbubblescouldpossiblybeusedassensitizersforhighintensityfocusedultrasound(HIFU)therapy,w

7、hichthermallycoagulatesdiseasedtissues,becausetheyhavebeenfoundtoenhancetheultrasonicallyinducedtemperatureriseoftissues.However,aseriousproblemariseswhenusingmicrobubblesinthattheyaretoobig(severalmicronsindiameter)toleakintotissuesfromthebloodvesselswhenintravenou

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