儿童患者中分离的746株肠球菌耐药性分析

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1、•实验研究•儿童患者中分离的746株肠球菌耐药性分析吕萍，张美和・宋文琪，甄景意.杨永弘，沈叙庄摘要：目的分析我院2001-2005年儿预患者临床标本中分离的肠球苗对10种常用抗菌药物的耐蔚性。方法药敏试验采用Kirby-Bauer琼脂扩散法.Nithocefin纸片检测B内酰胺鸽，数据处理采用WHONET5.3软件.结果746株肠球菌中粪肠球菌、屎肠球菌和坚切肠球菌分别占47・8%、47.2%和2.1%.未出现对万古昭素和替考拉宁耐药株，住院标本中分离的粪肠球菌对氨节西林、环丙沙址、高浓度庆大砖索和高浓度链爲索的耐药率高于门诊标本

2、分离株(P<0.01),住院标本中屎肠球菌对氨节西林的耐药率高于门诊标本(PV0.05)；除万古陆素、替考拉宁、红霧索、离浓度链硫索外•屎肠球菌对其他常用抗菌蔚的耐药率明显离于粪肠球菌(P<0.01).结论儿科肠球菌感染以医院感染为主，菌株对氨节西林、髙浓度庆大霉素和红霉素有较高耐药性•对万古霉索和替考拉宁均未出现耐药株.关键词：肠球菌：耐药性；抗生素中图分类号:R378文献标识码：B文章编号：1009-7708(2006)05-0321-04Analysisontheantibioticresistanceof746Enteroc

3、occusisolatesfromchildrenpatientsLUPing»ZHANGMei-he,SONGWen-qi♦ZHENJing-hui♦YANGYong-hong♦SHENXu-zhuang・(BeijingChildren'sHospital»CapitalUniversityofMedicalSciences,Beijing100045,China}Abstract:ObjectiveTostudytheantimicrobialresistancepatternoftheenterococcalisolates

4、collectedinapediatrichospitalfrom2001to2005・MethodsTheroutinemethodandMicro-scan•Phoenix100automaticmicrobialanalysissystemwereusedtoidentifytheorganisms.Kirby-Bauerdiskdiffusionmethodwasusedxoanalyzedrugresistance・Nitrocefinwasusedforthedetectionofp-lactamase.Datawer

5、eanalyzedbyWHONET5.3software.ResultsOfthe746isolates>E.faecalis^E.faeciumandE.duransaccounxedfor47.8%■47.2%and2.1%respectively.About54.2%,31.6%and7.9%oftheisolateswerei-solatedfromurine,bloodandsecretion.Noisolatewasfoundresistanttovancomycinorteicoplanin.Theresistance

6、ratestoampicillin,ciprofloxacin,highlevelgentamicinandhighlevelstreptomycinweresignificantlyhigherinnosocomialE.faecalisisolatesthantheisolatesfromoutpatients(PV0.01).TheresistancerateofE.faeciumtoampicillinwassignificantlyhigherinnosocomialisolatesthantheisolatesfromo

7、utpatients(P<0.05).Besidesvancomycin♦teicoplanineryxhromycinandhighlevelstreptomycin•theresistantratesofE.faeciumtootherantimicrobialagentsweresignificantlyhigherthanxhoseofE.faecalis(P

8、ialisolates.TheclinicalisolatesofEnterococcusarehighlyresistantxoampicillinthighlevelgentamicinanderythromycin.NoEnte