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1、PreparationofmicrocapsulesAbstractMicrocapsulesareminutecapsulesofsoliddrugsorliquiddrugs,itsdiametersare0.01~200pm,encapsulatedbypolyme匚Intheexperiment,sulfamerazinemicrocapsulesarepreparedbycomplexcoacervation,theshellthicknessisgelatiacaciamicrocapsules・Keywordsmicrocapsule;complexcoacerv
2、ation;microencapsulation;gelatinIntroductionMicroencapsulationisaneffectivemethodtowrapliquidand/orsolidmaterial,knownascorematerialbymicrocapsulesandhaspotentialextensiveapplicationsinfieldsofcosmetics,pesticides,pharmaceuticalandmedicalapplications,foods,biology,catalysis,carbonlesscopying
3、paperandmanyotherareas・DefineddiameterDTemplateassistedmethods:•Layer-by-Layerdeposition•Emulsion-basedprocesses•MicrofluidicsFig1•Microcapsules[3]DefinedshellthicknesshSelf-assemblymethods:・Layer-by-Layerdeposition・Colloidosomes-PolymerosomesMicrocapsulesareminutecapsulesofsoliddrugsorliqui
4、ddrugs,itsdiametersare0.01^200pm,encapsulatedbypolymer.Aftermicroencapsulated,drugcanbesustained-released,enhanceitsstability,maskitsunfavorableflavorandtaste,reduceitsirritationtogastrointestinaltract,decreasematchingtabooofmultiplemedicine,improveitsfluidityandcompressibilityofdrugsandmake
5、liquiddrugintosolid・Accordingtoclinicaldemanding,microcapsulescanbepreparedintopowders,capsules,tablets,irejectionsandointmentsetc.Fig2.OpticalmicroscopyimageofmicrocapsuleComplexcoacervationwasdescribedasatwo-stepprocesswithspontaneousaggregationowingtotheinteractionoftheoppositelychargedpo
6、lyelectrolyte,followedbyrearrangementoftheseaggregatesintocoacervatephase,apolymer-richsuperconcerttratedsolutionremaininginequilibriumwiththedilutephase・TheprocessofcomplexcoacervationtogetherwiththepropertiesoftheresultedmicrocapsulescanbeinflueneedbymanyphysicochemicalparameterssuchaspH,c
7、hargedensity,typeofions,ratioofpolyelectrolyteandionicstrengthespecially・Althoughcomplexesofproteinsandstrongpolyelectrolytetendtoformprecipitatesorsolid-likestructures,itisreportedthatthechargesofproteinandpolysaccharidemustbesufficientlylargetoin
