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1、CarcinogenesisAdvanceAccesspublishedSeptember28,20101©TheAuthor2010.PublishedbyOxfordUniversityPress.Allrightsreserved.ForPermissions,pleaseemail:journals.permissions@oxfordjournals.orgTemporalacquisitionofsequentialmutationsintheenhancerIIandbasalcorepromoterofHBVin
2、individualsathigh-riskforhepatocellularcarcinoma11,233345XinBai,YuZhu,YanJin,XiaGuo,GengsunQian,TaoyangChen,JingZhang,4611JinbingWang,JohnD.Groopman,JianrenGu,HongTu*1.StateKeyLaboratoryofOncogeneandRelatedGenes,CancerInstituteofShanghaiJiao-TongUniversity,SchoolofMe
3、dicine,2200-25XietuRoad,Shanghai200032,China2.ShanghaiMedicalCollege,FudanUniversity,138YixueyuanRoad,Shanghai200032,China3.DepartmentofMolecularDiagnostics,CancerInstituteofShanghaiJiao-TongUniversity,2200-25XietuRoad,Shanghai200032,China4.DepartmentofEtiology,Qidon
4、gLiverCancerInstitute/QidongTumorHospital,857MiddleJianghaiRoad,Qidong,Jiangsu226200,China5.DepartmentofChineseandWesternIntegrativeMedicinefortreatingliverdiseases,ShanghaiDahuaHospital,901LaohuminRoad,Shanghai200237,China6.BloombergSchoolofPublicHealth,JohnsHopkins
5、University,615NorthWolfeStreet,Baltimore,MD21205,USA*TowhomcorrespondenceshouldbeaddressedHongTu,MD,PhDCancerInstituteofShanghaiJiao-TongUniversity,SchoolofMedicine2200-25XietuRoad2Shanghai200032ChinaTel.86-21-64437301Fax86-21-64437196e-mail:tuhong@shsci.orgAbbreviat
6、ions:BCP,basalcorepromoter;CI,confidenceinterval;CP,corepromoter;EnhII,enhancerII;HBeAg,hepatitisBeantigen;HBsAg,hepatitisBsurfaceantigen;HBV,hepatitisBvirus;HCC,hepatocellularcarcinoma;OR,oddsratio;pre-cmRNA,precoremessengerRNA;pgmRNA,pregrenomicmessengerRNA;PCR,pol
7、ymerasechainreaction;SD,standarddeviation.Keywords:HepatitisBvirus;mutation;basalcorepromoter;enhancerII;hepatocellularcarcinoma.Abstract3ToinvestigatetherolesofmutationsinenhancerII(EnhII)andbasalcorepromoter(BCP)ofhepatitisBvirus(HBV)inhepatocellularcarcinoma(HCC),
8、wedeterminedthesequenceofEnhII/BCPin152HCCand136non-HCCpatientsfromahigh-incidenceareaofEastChina.Alongitudinalstudywasconductedon2
