Quality Control In Biological Databases

《Quality Control In Biological Databases》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、DataQualityIssues:Traps&PitfallsAshokKolaskarVice-ChancellorUniversityofPune,Pune411007.Indiapuvc@unipune.ernet.inCancercellgrowthappearstoberelatedtoevolutionarydevelopmentofplumpfruitsandvegetablesLargetomatoescanevolvefromwild,blueberry-sizetomatoes.Thegeneticmechanismresponsiblefor

2、thisissimilartotheonethatproliferatescancercellsinmammalians.Thisisacasewherewefoundaconnectionbetweenagriculturalresearch,inhowplantsmakeediblefruitandhowhumansbecomesusceptibletocancer.That'saconnectionnobodycouldhavemadeinthepast.CornellUniversityNews,July2000SizeofTomatoFruitfw2.2:A

3、QuantitativeTraitLocus(QTL)keytotheEvolutionofTomatoFruitSize.AnneFrary(2000)Science,289:85-88Singlegene,ORFX,thatisresponsibleforQTLhasasequenceandstructuralsimilaritytothehumanoncogenec-H-rasp21.Fruitsizealterations,impartedbyfw2.2alleles,aremostlikelytobeduetothechangesinregulationra

4、therthaninsequence/structureofprotein.GenomeUpdate:PublicdomainPublishedCompleteGenomes:59Archaeal9Bacterial36Eukaryal14OngoingGenomes:335Prokaryotic203Eukaryotic132Privatesectorholdsdataofmorethan100finished&unfinishedgenomes.ChallengesinPost-Genomicera:UnlockingSecretesofquantitativev

5、ariationForevenaftergenomeshavebeensequencedandthefunctionsofmostgenesrevealed,wewillhavenobetterunderstandingofthenaturallyoccurringvariationthatdetermineswhyonepersonismorediseasepronethananother,orwhyonevarietyoftomatoyieldsmorefruitthanthenext.Identifyinggeneslikefw2.2isacriticalfir

6、ststeptowardattainingthisunderstanding.ValueofGenomeSequenceDataGenomesequencedataprovides,inarapidandcosteffectivemanner,theprimaryinformationusedbyeachorganismtocarryonallofitslifefunctions.Thisdatasetconstitutesastable,primaryresourceforbothbasicandappliedresearch.Thisresourceisthees

7、sentiallinkrequiredtoefficientlyutilizethevastamountsofpotentiallyapplicabledataandexpertiseavailableinothersegmentsofthebiomedicalresearchcommunity.ChallengesGenomedatabaseshaveindividualgeneswithrelativelylimitedfunctionalannotation(enzymaticreaction,structuralrole)Molecularr