内源性调节性t细胞在sah后脑血管痉挛及脑损伤中的作用

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1、内源性调节性T细胞在SAH后脑血管痉挛及脑损伤中的作用汇报人：张金卉导师：孙保亮研究的目的及意义SAH后脑血管痉挛、炎症反应及神经功能预后的改善是一个非常复杂的病理、生理、临床过程。虽然进行了大量研究，为止其发生机制仍未完全明了。研究小鼠体内内源性调节性T细对SAH后脑血管痉挛、炎症反应及神经功能预后的改善仍将是今后一个时期的热点。随着研究的逐渐深入，将会对内源性调节性T细胞移植SAH的临床治疗及神经功能预后带来深远的影响。国内外相关文献TheKineticsofLymphocyteSubsetsandMacrophagesinSubarachnoidSpaceAfterSubara

2、chnoidHemorrhageinRatsithasbeensuggestedthathumoralimmunityplaysaroleinthepathogenesisofcerebralvasospasmaftersubarachnoidhemorrhage,therehasbeennoquantitativeassayforcellularimmunity.Westudiedthekineticsofimmunecellsinthesubarachnoidspaceaftersubarachnoidhemorrhageintherat.Aserialresponseofimmu

3、noreactivecells,whichresemblesthatofthechronicallergicreactionobservedinautoimmunediseasesordelayed-typehypersensitivity,existsinthesubarachnoidspaceaftersubarachnoidhemorrhage.Thepresentresultssuggestthattheinitialresponseincellularimmunity,whichisfollowedbyhumoralimmunityandeicosanoidreactions

4、,playsaroleinelicitingthedevelopmentofcerebralvasospasm.蛛网膜下腔出血后脑血管痉挛分子机制的研究进展与NO代谢有关的CVSK通道活性的改变文氧合血红蛋白的作用本磷酸二酯酶一V的作用本NO和ET一1的平衡失调与NO代谢无关的CVSRas蛋白的作用前列环素与血栓烷A2失衡自由基与脂质过氧化物增多血管加压素的作用ca代谢紊乱Statin-InducedT-LymphocyteModulationandNeuroprotectionFollowingExperimentalSubarachnoidHemorrhageStatinsinf

5、luenceimmunesystemactivitiesthroughechanismsindependentoftheirlipidloweringproperties.Tcellscanbesubdividedbasedoncytokinesecretionpatternsintotwosubsets:T-helpercellstype1(Th1)andtype2(Th2).IndependentlaboratorystudieshaveshownstatinstobepotentinducersofaTh2switchinimmunecellresponseandbeneurop

6、rotectiveinseveralmodelsofcentralnervoussystem(CNS)disease.Thisstudywasthefirsttoevaluatetheimmunemodulatingeffectsofstatinsinsubarachnoidhemorrhage(SAH).ThepresentstudyelucidatedthepotentialroleofaTh2immuneswitchinstatinprovidedneuroprotectionfollowingSAH.Matrixmetalloproteinase-9concentrationi

7、nthecerebralextracellularfluidofpatientsduringtheacutephaseofaneurysmalsubarachnoidhemorrhageElevatedcerebralinterstitialpro-MMP-9relatestoearlybraininjuryinaSAHpatients.Alargerprospectivestudyshouldbeperformedtoconfirmwheth