clinical_pharmacokinetics_samplechapter

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1、1BasicpharmacokineticsSorayaDhillonandKirenGillAimsandlearningoutcomesPharmacokineticsisafundamentalscientificdisciplinethatunderpinsappliedtherapeutics.Patientsneedtobeprescribedappropriatemedicinesforaclinicalcondition.Themedicineischosenonthebasiso

2、fanevidence-basedapproachtoclinicalpracticeandassuredtobecompatiblewithanyothermedicinesoralternativetherapiesthepatientmaybetaking.Thedesignofadosageregimenisdependentonabasicunder-standingofthedruguseprocess(DUP).Whenfacedwithapatientwhoshowsspecifi

3、cclinicalsignsandsymptoms,pharmacistsmustalwaysaskafundamentalquestion:‘Isthispatientsufferingfromadrug-relatedproblem?’Oncethisissueisevaluatedandaclinicaldiagnosisisavail-able,thepharmacistcanapplytheDUPtoensurethatthepatientisprescribedanappropria

4、temedicationregimen,thatthepatientunder-standsthetherapyprescribed,andthatanagreedconcordanceplanisachieved.PharmacistsusingtheDUPconsider:●Needforadrug●Choiceofadrug●Goalsoftherapy●Designofregimen–Route–Doseandfrequency–Duration●Monitoringandreview●

5、CounsellingOnceaparticularmedicineischosen,theprinciplesofclinicalpharmaco-kineticsarerequiredtoensuretheappropriateformulationofdrugischosenforanappropriaterouteofadministration.Onthebasisofthepatient’sdrughandlingparameters,whichrequireanunderstand

6、ingof2Basicpharmacokineticsabsorption,distribution,metabolismandexcretion,thedosageregimenforthemedicineinaparticularpatientcanbedeveloped.Thepharmacistwillthenneedtoensurethattheappropriateregimenisprescribedtoachieveoptimalefficacyandminimaltoxicity

7、.Pharmaciststhenensurethattheappropriatemonitoringisundertakenandthatthepatientreceivestheappropriateinformationtoensurecompliance.Clinicalpharmaco-kineticsisthusafundamentalknowledgebasethatpharmacistsrequiretoensureeffectivepracticeofpharmaceutical

8、care.Theaimofthischapteristoprovidethepractisingclinicalpharma-cistwiththeappropriateknowledgeandskillsofappliedclinicalphar-macokinetics,whichcanbeappliedineverydaypractice.Theobjectivesforthischapteraretoenablethereaderto:●Statetherationaleforusing