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大小:207.83 KB
页数:44页
时间:2019-08-09
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1、1BasicpharmacokineticsSorayaDhillonandKirenGillAimsandlearningoutcomesPharmacokineticsisafundamentalscientificdisciplinethatunderpinsappliedtherapeutics.Patientsneedtobeprescribedappropriatemedicinesforaclinicalcondition.Themedicineischosenonthebasiso
2、fanevidence-basedapproachtoclinicalpracticeandassuredtobecompatiblewithanyothermedicinesoralternativetherapiesthepatientmaybetaking.Thedesignofadosageregimenisdependentonabasicunder-standingofthedruguseprocess(DUP).Whenfacedwithapatientwhoshowsspecifi
3、cclinicalsignsandsymptoms,pharmacistsmustalwaysaskafundamentalquestion:‘Isthispatientsufferingfromadrug-relatedproblem?’Oncethisissueisevaluatedandaclinicaldiagnosisisavail-able,thepharmacistcanapplytheDUPtoensurethatthepatientisprescribedanappropria
4、temedicationregimen,thatthepatientunder-standsthetherapyprescribed,andthatanagreedconcordanceplanisachieved.PharmacistsusingtheDUPconsider:●Needforadrug●Choiceofadrug●Goalsoftherapy●Designofregimen–Route–Doseandfrequency–Duration●Monitoringandreview●
5、CounsellingOnceaparticularmedicineischosen,theprinciplesofclinicalpharmaco-kineticsarerequiredtoensuretheappropriateformulationofdrugischosenforanappropriaterouteofadministration.Onthebasisofthepatient’sdrughandlingparameters,whichrequireanunderstand
6、ingof2Basicpharmacokineticsabsorption,distribution,metabolismandexcretion,thedosageregimenforthemedicineinaparticularpatientcanbedeveloped.Thepharmacistwillthenneedtoensurethattheappropriateregimenisprescribedtoachieveoptimalefficacyandminimaltoxicity
7、.Pharmaciststhenensurethattheappropriatemonitoringisundertakenandthatthepatientreceivestheappropriateinformationtoensurecompliance.Clinicalpharmaco-kineticsisthusafundamentalknowledgebasethatpharmacistsrequiretoensureeffectivepracticeofpharmaceutical
8、care.Theaimofthischapteristoprovidethepractisingclinicalpharma-cistwiththeappropriateknowledgeandskillsofappliedclinicalphar-macokinetics,whichcanbeappliedineverydaypractice.Theobjectivesforthischapteraretoenablethereaderto:●Statetherationaleforusing
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