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1、Pain,28(1987)379-393379ElsevierPAI01006Anklejointuratearthritis(AJUA)inrats:analternativeanimalmodelofarthritistothatproducedbyFreundsadjuvantTerenceJ.CoderreandPatrickD.WallCerebralFunctionsReseurehGroup,DepartmentofAnatomyandEmhtyologv,UniversitvCollegeLondon,LondonWCJE6BT(U.K..i(Received
2、20May1986,accepted1August1986)SummaryInjectionofsodiumuratecrystalsintooneanklejointintheratproducesarthritiswhichisfullydevelopedwithin24h.Thetime-courseanddose-responseofassociatedinflammationandsensoryabnormalitiesaredesctibed.Followingintra-articularsodiumurateratsreducetheweightplacedo
3、nthepawofthetreatedhindlimbanddevelopalimpintheirgait.Theankleswellsandbecomesmoresensitivetopressureandpassivemovements.Touch,pressureandthermalstimuliappliedtothefootdistaltothetreatmentproducedecreasedresponses,presumablybecauseactiveflexionmovementsarenoxious.Jointpathologyisreflectedby
4、tissueoedemaandtheinfiltrationofpolymorphonuclearleucocytes.However,thereisnodestructionordecreaseindensityofbone.Itisproposedthatthismodelofarthritismayhaveethicalandscientificadvantagesoveradjwantarthritisinthestudyofsomeaspectsoftheneuralmechanismsofarthritis.Keywords:Anklejointarthritis
5、;Sodiumurate;Arthritis;FreundsadjuvantIntroductionAgrowingnumberofresearchersstudyinflammationandchronicpaininanimalsbyinducingarthritiswithaninjectionofFreundsadjuvantintothetailofrats[1,5,6,11,20].Inadditiontoproducinginflammation[l&21,24],suchatreatmentproduceschronicpainandhyperalgesiai
6、ntheaffectedjoints.Chronicpainisindicatedbypersistentscratching[1,8],reducedmotoractivity[1,12],weightloss[6,8],increasedvocalizationwheninclosecontactwithotherrats[20],increasedrespirationorhyperventilation[7],andtheincreasedself-administrationofanalgesicagents[5,6].Hyperalgesia,whichcontr
7、ibutestochronicpain,isindicatedbyCorrespondenceto:Prof.P.D.Wall,CerebralFunctionsResearchGroup,DepartmentofAnatomyandEmbryology,UniversityCollegeLondon,GowerStreet,LondonWClE6BT,U.K.0304-3959/87/$03.50Q1987ElsevierSciencePublishersB.V.(BiomedicalDivision
