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1、2.01TheIntersectionofStrategyandDrugResearchWHMoos,SRIInternational,MenloPark,CA,USAandUniversityofCaliforniaSanFrancisco,SanFrancisco,CA,USA&2007ElsevierLtd.AllRightsReserved.2.01.1Overview22.01.2OrganizationalAspects42.01.2.1Introduction42.01.2.2MajorIssuesIncludingAttrition1
2、12.01.2.2.1Newproductdevelopmenttoolkitforthecriticalpath112.01.2.3ProjectManagementIncludingTeams122.01.2.3.1Overallprojectassessmentscheme142.01.2.3.2Targetvalidation152.01.2.3.3Selecteddecisionpointsandtransitionsfromdiscoverytonewdrugapplication162.01.2.4RecruitmentandManag
3、ementofHumanResources162.01.2.4.1Guidelinesformedicinalchemistsearlyintheircareers172.01.2.5MultipleSitesIncludingOutsourcing192.01.2.6ContrastingBiotechwithPharmaandInnovation202.01.2.7BusinessDevelopmentIncludingAspectsofPortfolioManagement252.01.2.8DrugDevelopment262.01.3Dru
4、gDiscovery312.01.3.1Introduction312.01.3.2Technologies322.01.3.3ChemicalBiologyandChemicalGenomics442.01.3.4FromSmallMoleculestoMacromolecules472.01.3.5ComputationalApproaches482.01.3.6EvolutionofPreclinicalResearchoverSeveralDecades522.01.3.7TransitionfromResearchtoDevelopment
5、,IncludingAbsorption,Distribution,Metabolism,Excretion,andToxicity542.01.3.8ThePerspectiveofSuccessfulDrugHunters542.01.4Targets562.01.4.1TransportersasanExampleofanImportantClassofTargets562.01.4.1.1Currentnomenclature582.01.4.1.2Gene/molecularbiologyclassificationandproteinstr
6、ucture592.01.4.1.3Physiologicalfunction602.01.4.1.4Prototypicalpharmacologyandtherapeutics622.01.4.1.5Geneticdiseases662.01.4.1.6Newdirections672.01.4.2GeneralDiscussionofTargets682.01.4.3ProjectSelection732.01.4.4OtherTargetClasses73References7612TheIntersectionofStrategyandDr
7、ugResearch2.01.1OverviewInthisoverview,readerswillfindapreviewofwhatfollows.Wewillstartwithoneofthefundamentalissuesfacingtheindustrytoday.Asmaybeevidentfromevenacursoryreadingofthedailynewspaper,drugresearchisacomplicated,time-consuming,andexpensiveprocess.Itistheproverbialhigh
8、-risk,high-payoffindustry.Alarmingly,thecapitalized,ou
