资源描述：
《A Practical Approach to the Diagnosisand Treatment of Vitiligo in Children一种实用的诊断方法 儿童白癜风的治疗》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、APracticalApproachtotheDiagnosisandTreatmentofVitiligoinChildrenKhaledEzzedine,MD,PhD,aNanetteSilverberg,MDbVitiligoisacommoninflammatoryskindiseasewithaworldwideabstractprevalenceof0.5%to2.0%ofthepopulation.Inthepediatricpopulation,theexactprevalenceofvitiligoisunknown,althou
2、ghmanystudiesstatethatmostcasesofvitiligoareacquiredearlyinlife.Thediseaseisdisfiguring,withamajorpsychologicalimpactonchildrenandtheirparents.Halfofvitiligocaseshaveachildhoodonset,needingthusatreatmentapproachthatwillminimizetreatmentsideeffectswhileavoidingpsychologicalimpa
3、cts.Managementofvitiligoshouldtakeintoaccountseveralfactors,includingextension,psychologicalimpact,andpossibleassociationswithotherautoimmunediseases.Thisreviewdiscussestheepidemiologyofvitiligoandoutlinesthevariousclinicalpresentationsassociatedwiththedisorderandtheirdifferen
4、tialdiagnosis.Inaddition,thepathophysiologyandgeneticdeterminants,thepsychologicalimpactofvitiligo,andmanagementstrategiesarereviewed.Vitiligoisachronic,acquiredEPIDEMIOLOGYOFPEDIATRICVITILIGOdepigmentingconditionoftheskin,andsometimesofthemucosa,Theprevalenceofvitiligoworldwi
5、dethatresultsintheselectivelossrangesfrom0%to2.16%ofthe16aDepartmentofDermatology,HenriMondorHospitalandofmelanocytes.Vitiligohasbeenpopulation,withapproximatelyone-EpiDermE,UniversitéParis-EstCréteilVal-de-Marne,Créteil,reportedsinceancienttimesandathirdtoone-halfofallcasesha
6、vingFrance;andbDepartmentofDermatologyandPediatrics,descriptionofitexistsintheLatinonsetinchildhood.7ThereappeartoMountSinaiSt.Luke's-RooseveltandBethIsraelMedicalmedicalclassicDeMedicinaofCelsusbe2subsetsofpatientswithvitiligo:Centers,NewYork,NewYorkduringthesecondcentury.2,3
7、Thethosewithearlyonset(12yearsofageDrsEzzedineandSilverbergconceptualizedandnamemightcomefromtheLatinoryounger)whohavemorehalonevi,designedthestudy,performeddatacollection,“vitium,”meaningdefectorblemish.4Koebnerphenomenon(KP)(lesionaldraftedtheinitialmanuscript,carriedoutthei
8、nitialanalyses,reviewedandrevisedthemanuscript,andAlthoughvit
