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《The Drosophila gene Medea demonstrates the requirement for differentDrosophila gene Medeaclasses of Smads in dpp signaling展示了不同的要求 DPP信令中的SMADS类》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Development125,1519-1528(1998)1519PrintedinGreatBritain©TheCompanyofBiologistsLimited1998dev5188TheDrosophilageneMedeademonstratestherequirementfordifferentclassesofSmadsindppsignalingPradeepDas,LisaL.Maduzia,HuangWang,AlyceL.Finelli*,Seo-HeeCho,MarshaM.Sm
2、ithandRichardW.Padgett†WaksmanInstitute,DepartmentofMolecularBiologyandBiochemistry,CancerInstituteofNewJersey,RutgersUniversity,Piscataway,NJ08854,USA*Presentaddress:SectionofInfectiousDiseases,YaleUniversitySchoolofMedicine,NewHaven,CT06520,USA†Authorfor
3、correspondence(e-mail:padgett@mbcl.rutgers.edu)Accepted20January;publishedonWWW18March1998SUMMARYSignalsfromtransforminggrowthfactor-b(TGF-b)alsoblocksdppsignalingduringlaterdevelopment,ligandsaretransmittedwithinthecellbymembersofthesuggestingthatMedea,li
4、keMad,isuniversallyrequiredforSmadfamily,whichcanbegroupedintothreeclassesbaseddppsignaling.Furthermore,weshowthatthenecessityforonsequencesimilarities.Ourpreviousidentificationofthesetwocloselyrelated,non-redundantSmads,isduetobothclassIandIISmadsfunctioni
5、nginasinglepathwaytheirdifferentsignalingproperties–uponactivationoftheinC.elegans,raisedtheissueofwhethertherequirementDpppathway,MadisrequiredtoactivelytranslocateforSmadsderivedfromdifferentclassesisageneralMedeaintothenucleus.Theseresultsprovideaparadi
6、gmfeatureofTGF-bsignaling.Wereportherethefor,anddistinguishbetween,therequirementforclassIidentificationofanewDrosophilaclassIISmad,Medea,aandIISmadsinDpp/BMPsignaling.closehomologofthehumantumor-suppressorgeneDPC4.EmbryosfromgermlineclonesofbothMedeaandMad
7、(aclassISmad)areventralized,asareembryosnullfortheKeywords:TGF-b,Smad,Mad,BMP,Patternformation,TGF-b-likeliganddecapentaplegic(dpp).LossofMedeaDrosophila,MedeaINTRODUCTIONligandsbindtheirtypeIandIIreceptorssimultaneously,ratherthansequentially.Receptorsfor
8、Dpp,namelySaxophone(Sax)Membersofthetransforminggrowthfactor-b(TGF-b;andThickveins(Tkv;typeIreceptors),andPunt(typeIIRobertsetal.,1981)superfamilyhaveimportantrolesinthereceptor)havebeenidentifiedandshowntober
