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《The Cellular Electrophysiologic Mechanismof the Dual Actions of Disopyramideon Rabbit Sinus Node Function细胞电生理机制 双吡酰胺的双重作用 兔窦房结功能的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、1216CIRCULATIONVOL66,No6,DECEMBER1982midephosphate.AmJCardiol35:282,197521.SwirynS,BauernfeindRA,WyndhamCRC,DhingraRC,Palileo20.ShenasaM,GilbertCJ,SchmidtDH,AkhtarM:ProcainamideandE,StrasbergB,RosenKM:Effectsoforaldisopyramidephosphateretrogradeatrioventricularnodalconductioninman.Ci
2、rculationoninductionofparoxysmalsupraventriculartachycardia.Circula-65:355,1982tion64:169,1981TheCellularElectrophysiologicMechanismoftheDualActionsofDisopyramideonRabbitSinusNodeFunctionTAKAOKATOH,M.D.,HRAYRS.KARAGUEUZIAN,PH.D.,JAYJORDAN,M.D.,ANDWILLIAMJ.MANDEL,M.D.withthetechnicala
3、ssistanceofAvileMcCulleniSUMMARYTodeterminethecontributionofdisopyramide'ssuggestedopposingdirectdepressantandindirectacceleratoryactionsonsinusnodefunction,westudiedtheeffectsofdisopyramide,1x10-7to1X10-4M,onisolatedrabbitsinusnodepreparationsusingstandardmicroelectrodetechniques.Tr
4、ansmem-branepotentialswererecordedsimultaneouslyfromthesinusnodeandadjoiningcristaterminalisarea.Disopyramide,asmuchas1x10-5M,hadnoeffectsonthesinuscyclelength.Ataconcentrationof1x10-4M,sinuscyclelengthwassignificantlyprolongedduetoprolongationofthesinusnodalactionpotentialduration.D
5、uringcholinergicblockadewithatropine,1x10-6M,disopyramide,x10-7to1xi0-4M,significantlyprolongedsinuscyclelengthasaresultofaprolongationofthesinusnodalactionpotentialdurationandadecreaseoftheslopeofphase4depolarization.Duringcholinergicstimulationwithcarbamylcholine,1x10-9M,disopyrami
6、de,1x10-to1x10-6M,tendedtoreversecarbamylcholine-inducedprolongationofthesinuscyclelength(NS).ThisacceleratoryactionofdisopyramidewasDownloadedfromhttp://ahajournals.orgbyonAugust6,2018causedbyasignificantincreaseoftheslopeofphase4depolarization.Disopyramide,1x0-7to1x10-4M,hadnosigni
7、ficanteffectsoncorrectedsinusnoderecoverytimeoronsinoatrialconductiontimeunderanyconditionsstudied.Weconcludethatdisopyramidehasadirectdepressantactiononnormalsinusnodecellsattheuppertherapeuticandtoxiclevels,whichisenhancedduringcholinergicblockade,andthatdisopyramide'sacceleratorya
8、ctionappears
