LED Photoprevention Reduced MED Response FollowingLED光预防：减少MED响应 多重LED曝光

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1、LasersinSurgeryandMedicine40:106112(2008)LEDPhotoprevention:ReducedMEDResponseFollowingMultipleLEDExposures1,21DanielBarolet,MD,FRCPC*andAnnieBoucher,PhD1RoseLab,SkinOpticsLaboratory,Montreal,Quebec,Canada2DepartmentofMedicine,McGillUniversity,Montreal,CanadaBackgrou

2、ndandObjectives:AsphotoprotectionwithINTRODUCTIONtraditionalsunscreenpresentssomelimitations,theuseofThesolarradiationthatreacheshumanskinrangesfromnon-traditionaltreatmentstoincreaseskinresistanceto290to4,000nmandincludesultraviolet(UV)radiation:ultraviolet(UV)induc

3、eddamagewouldproveparticularlyUV-B(290320nm),UV-A(320400nm)whichcanbeappealing.ThepurposeofthispilotstudywastotestfurthersubdividedintoUV-AI,orfarUV-A(340400nm)thepotentialofnon-thermalpulsedlight-emittingdiodeandUV-AIIornearUV-A(320340nm),visiblelight(400(LED)treatm

4、ents(660nm)priortoUVexposurein700nm)andinfraredradiation(IR;7004,000nm)[1].theinductionofastateofcellularresistanceagainstSmallamountsofUVirradiationareessentialfortheUV-inducederythema.productionofvitaminD,yetwhentheskinissubjectedtoStudyDesign/MaterialsandMethods:T

5、hirteenexcessiveradiation,deleteriouseffectsmayoccur.healthysubjectsandtwopatientswithpolymorphouslightItiscommonlyacceptedthattheUVrange(<400nm)eruption(PLE)wereexposedto5,6,or10LEDtreatmentsexposureisresponsibleforalmostalldeleteriousphoto-(660nm)onanEXPERIMENTALan

6、teriorthighregion.inducedeffectsonhumanskin.SomeofthepossibleIndividualbaselineminimalerythemadoses(MED)weremechanismsforUVskindamagearecollagenbreakdown,thendetermined.UVradiationwasthereafterperformedtheformationoffreeradicals,interferingwithDNArepair,ontheLEDEXPER

7、IMENTALandCONTROLanteriorandinhibitingtheimmunesystem[2].Atthistime,thighareas.Finally,24hourspost-UVirradiation,LEDminimizingtheamountofUVirradiationthatreachesthepre-treatedMEDresponseswerecomparedtothenon-skinremainstheonlymethodforprotectingskinagainsttreatedsite

8、s.UV-induceddamage.ThisisachievedmostlybyavoidanceResults:Reductionoferythemawasconsideredsignificantofsunexposureandtheuseoftraditi