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1、REVIEWARTICLEFromfunctionalgenomicstosystemsbiologyMeetingreportbasedonthepresentationsatthe3rdEMBLBiennialSymposium2006(Heidelberg,Germany)SergiiIvakhnoInstituteforAdaptiveandNeuralComputation,SchoolofInformatics,UniversityofEdinburgh,UKKeywordsThisreviewdiscussesthetalkspres
2、entedatthethirdEMBLBiennialSym-DNAmicroarraymedicalapplications;posium,Fromfunctionalgenomicstosystemsbiology,heldinHeidelberg,functionalgenomics;geneticinteractionGermany,14–17October2006.Currentissuesandtrendsinvarioussub-networks;networksbiology;signallingfieldsoffunctionalg
3、enomicsandsystemsbiologyareconsidered,includingnetworks;systemsbiologyanalysisofregulatoryelements,signallingnetworks,transcriptionnetworks,Correspondenceprotein–proteininteractionnetworks,geneticinteractionnetworks,medicalS.Ivakhno,InstituteforAdaptiveandNeuralapplicationsofD
4、NAmicroarrays,andmetagenomics.SeveraltechnologicalComputation,SchoolofInformatics,advancesinthefieldsofDNAmicroarrays,identificationofregulatoryele-UniversityofEdinburgh,E4,5ForrestHill,mentsinthegenomesofhighereukaryotes,andMSfordetectionofpro-EdinburghEH12QL,UKteininteractions
5、areintroduced.MajordirectionsoffuturesystemsbiologyFax:+44(0)1316506899researcharealsodiscussed.Tel:+44(0)1316676000,ext.01316684266E-mail:s0567096@sms.ed.ac.uk(Received30January2007,revised1March2007,accepted12March2007)doi:10.1111/j.1742-4658.2007.05794.xbeyond,(d)Towardsfun
6、ctionalinteractionnetworks,Introduction(e)Systemslevelanalysis:fromorganismstocommu-ThethirdEMBLBiennialSymposium,Fromfunc-nities.tionalgenomicstosystemsbiology,washeldinHeidel-Table1givesabroadoverviewoftopicspresentedberg,Germany,14–17October2006.Thetitleoftheatthemeetingacc
7、ordingtothesystemsbiologyconferenceclearlystatesthemajorchallengesandapplications,typesofhigh-throughputtechniques,issuesthatwereaddressedbythespeakers–howtoandbiologicalnetworks.Fromthesheernumberofcombinedifferent‘omics’technologiesandbioinfor-varioushigh-throughputgenomicap
8、proachesdes-maticscomputationalmethodologiestoaddresscribedat
