supramolecular templating in thermodynamically controlled synthesis

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1、SupramolecularChemistryAndSelf-assemblySpecialFeature:SupramoleculartemplatinginthermodynamicallycontrolledsynthesisRicardoL.E.Furlan,SijbrenOtto,andJeremyK.M.SandersPNAS2002;99;4801-4804;originallypublishedonlineMar5,2002;doi:10.1073/pnas.022643699Thisinformationiscurre

2、ntasofNovember2006.OnlineInformationHigh-resolutionfigures,acitationmap,linkstoPubMedandGoogleScholar,etc.,can&Servicesbefoundat:www.pnas.org/cgi/content/full/99/8/4801ReferencesThisarticlecites24articles,1ofwhichyoucanaccessforfreeat:www.pnas.org/cgi/content/full/99/8/4

3、801#BIBLThisarticlehasbeencitedbyotherarticles:www.pnas.org/cgi/content/full/99/8/4801#otherarticlesE-mailAlertsReceivefreeemailalertswhennewarticlescitethisarticle-signupintheboxatthetoprightcornerofthearticleorclickhere.SubspecialtyCollectionsThisarticle,alongwithother

4、sonsimilartopics,appearsinthefollowingcollection(s):SupramolecularChemistryandSelf-AssemblySpecialFeaturewww.pnas.org/cgi/collection/supra_chemRights&PermissionsToreproducethisarticleinpart(figures,tables)orinentirety,see:www.pnas.org/misc/rightperm.shtmlReprintsToorderr

5、eprints,see:www.pnas.org/misc/reprints.shtmlNotes:PerspectiveSupramoleculartemplatinginthermodynamicallycontrolledsynthesisRicardoL.E.Furlan*,SijbrenOtto†‡,andJeremyK.M.Sanders†‡*UniversidadNacionaldeRosario,FacultaddeCienciasBioquı´micasyFarmace´uticas,Suipacha,531,2000

6、Rosario,Argentina;and†DepartmentofChemistry,UniversityofCambridge,LensfieldRoad,CambridgeCB21EW,UnitedKingdomThisperspectivehasasimplemessage:larrecognitionhasbecomeaversatiletoolCovalentsynthesisunderthermody-thatenablescontroloverequilibriumsys-namiccontrolcanbeapowerfu

7、ltoolfortem.Selectiverecognitionofoneofthepreparingmechanicallyinterlockedstruc-componentsinanequilibriumsystemwillturesandspecificmacrocyclesinhighresultinthecreationofanadditionalwellinyieldandatthesametimeserveasantheGibbsenergylandscape(Fig.1).Ifthisengineforthecreat

8、ionofdynamiccom-wellisdeepenough,therecognizedcom-binatoriallibraries(DCLs),whicharere-poundwilldominat