regulation of gene-5+3-1s

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1、李迺昶DrNaichangLiMSc.MD.PhD.DepartmentofBiochemistry&molecularbiology目录1.IntroductionandBiomedicalimportance1.Geneamplification2.Generearrangement3.SynthesisoftheprimaryRNAtranscript(transcription)4.PosttranscriptionalmodificationofmRNA5.MessengerRNAdegradation6.Proteinsy

2、nthesis(translation)7.Posttranslationalmodificationofproteins8.Proteintargetingandtransport9.Proteindegradation目录2.RegulationofProkaryoticGeneExpression3.Specialfeaturesareinvolvedinregulationofeukaryoticgenetranscription4.Generegulationinprokaryotesandeukaryotesdiffers

3、inimportantrespects目录1.Introduction(1)Gene:is"alocatableregionofgenomicsequence,correspondingtoaunitofinheritance,whichisassociatedwithregulatoryregions,transcribedregions,andorotherfunctionalsequenceregions".(2)Geneexpression:Theprocessofproducingabiologicallyfunctiona

4、lmoleculeofeitherRNAorproteiniscalledgeneexpression.Gene:25000(3)RegulationofGeneexpression?目录Regulationofgeneexpressionalabelforthecellularprocessesthatcontroltherateandmannerofgeneexpression.Acomplexsetofinteractionsbetweengenes,RNAmolecules,proteins(transcriptionfact

5、ors)andothercomponentsoftheexpressionsystemdeterminewhenandwherespecificgenesareactivatedandtheamountofproteinorRNAproductproduced.forexampletotriggerdevelopmentalpathways,respondtoenvironmentalstimuli,oradapttonewfoodsources.目录BiomedicalimportanceRegulatedexpressionofg

6、enesisrequiredfordevelopment,differentiation,andadaptation维持细胞分化和个体发育适应环境、维持生长和增殖目录EffectsofPositiveandNegativeRegulationonGeneExpressionRateofGeneRepressorActivator目录BiologicSystemsExhibitThreeTypesOfTemporalResponsesToARegulatorySignaltypeAresponsetypeBresponsetypeCre

7、sponse目录typeAresponse：dependentuponthecontinuedpresenceoftheinducingsignal.依赖诱导信号typeBresponse：transienteveninthecontinuedpresenceoftheregulatorysignal.typeCresponse：Thesignalactsasatrigger.目录Principlesofgeneregulation•Theexpressionofgenesisregulatedbyprocessesthataffec

8、ttheratesatwhichgeneproductsaresynthesizedanddegraded.Initiationoftranscriptionisacrucialregulationpointforbot