Respiratory Regulation

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1、VirtualExperimentRespiratoryRegulationDr.LLWangEmail:wanglinlin@zju.edu.cnRm608,BlockB,ResearchBuilding,SchoolofMedicine,ZijingangCampus[Purpose]¢Toinvestigatetheeffectsofcarbondioxide,hypoxia,deadspace,[H+]andvagusnervestimulationonrespiratorymovements.[Principle]¢The

2、rhythmicrespiratorymovementswhichcausethepulmonaryventilationarecontrolledbytherespiratorycenter.¢Respiratoryneuronsinthemedullacontrolinspirationandexpiration¢Neuronsintheponsinfluencetherateanddepthofventilation¢Rhythmicpatternofbreathingarisesfromanetworkofspontaneo

3、uslydischargingneurons¢Ventilationissubjecttomodulationbychemicalfactorsandbyhigherbraincenters¢Manyfactorsaffecttherespiratorycenterthroughreflexmechanismstoregulatetheamplitudeandfrequencyofventilation.BasicRespiratoryCenter¢BrainStem¢Medullaoblongata¢PonsCentralChem

4、oreceptorChemoreceptorNeuronsNeartheventralsurfaceofthemedullaPeripheralChemoreceptors¢Aorticandcarotidbody¢responsetochangesinPO,PCOandpH22EffectofArterialPCOonalveolarventilation2¢mostly(80%)mediatedbythecentralchemoreceptor¢20%oftheresponseisduetoperipheralchemorece

5、ptorstimulationEffectofArterial[H+]onalveolarventilation¢mediatedbytheperipheralchemoreceptorstimulationEffectofArterialPOonalveolarventilation2¢mediatedbytheperipheralchemoreceptorstimulation[Experimentalobject]¢Rabbit[VirtualExperimentProcedure]¢VirtualExperimentProc

6、edurewillbedemonstrated.¢Openthevirtualexperimentwindowofrespiratoryregulation¢Movethemousetoscalpelicon.Clicktheleftkeyofmousetomovescalpeltotheneckareaoftherabbittoactivatetwovideowindows.(Fig.4-2).Oneisabouttheprocedureofseparatingthevagusnervesbesidethetrachea.Theo

7、therisaboutthemethodofendotrachealintubation.¢Clickthe“measure”buttontorecordthecurveofrespiratorymovements.¢Measurethechangesofamplitudeandfrequencyofrespiratorymovements.¢Experimentitems¢Normalcondition¢CO2¢Hypoxia(N2)¢Deadspace(latextube(40cmlength)+¢Highconcentatio

8、nof[H]¢VagusnervesResultsTable4-1:EffectsofCO,hypoxia,deadspace,[H+]andvagusnerveson2therespiratorymovementinrabbit.F