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1、PROGRESSREPORTBiologicalImagingwww.advmat.deRecentAdvancesofOpticalImagingintheSecondNear-InfraredWindowKenry,YukunDuan,andBinLiu*overallprognosisandtreatmentoutcomesThenear-infraredwindowbetween1000and1700nm,commonlytermedofpatients.[6]Asaresult,activeendeavorsthe“secondnear-infrared(
2、NIR-II)window,”hasquicklyemergedasahighlyhavebeenundertakentoenhancetheattractiveopticalregionforbiologicalimaging.Incontrasttoconventionalresolution,sensitivity,penetrationdepth,imaginginthevisibleregionbetween400and700nm,aswellasinthefirstaccuracy,andacquisitiontimeofbiolog-icalimagi
3、ngthroughingeniousinnova-NIR(NIR-I)windowbetween700and900nm,NIR-IIbiologicalimagingtionsandadvancementsinitsimagingoffersnumerousmerits,includinghigherspatialresolution,deeperprobesandinstrumentation.penetrationdepth,andloweropticalabsorptionandscatteringfrombiologicalConventionalnonin
4、vasivebiologicalsubstrateswithminimaltissueautofluorescence.Noninvasiveimagingimagingmethods,notablyluminescencetechniques,specificallyNIR-IIfluorescenceandphotoacoustic(PA)imaging,andphotoacoustic(PA)imaging,typicallyoperateinthefirstnear-infrared(NIR-I)haveembodiedtheattractivenessof
5、NIR-IIopticalimaging,withseveralregionoftheelectromagneticspec-NIR-IIcontrastagentsdemonstratingsuperiorperformancetotheclinically[7]trumbetween700and900nm.WhileapprovedNIR-Iagents.Consequently,NIR-IIbiologicalimaginghasbeenimagingattheNIR-Iwindowhasbeenincreasinglyexploredduetoitstrem
6、endouspotentialforpreclinicalstudiesthegoldstandardforthelastseveraldec-andclinicalutility.Herein,theprogressofopticalimagingintheNIR-IIadesandhascontributedconsiderablytowindowisreported.Startingwithhighlightingtheimportanceofbiologicaltheadvancementsofbiologyandmedi-cine,therearestil
7、lplentyofroomsforimagingintheNIR-IIspectralregion,theemergenceandlatestdevelopmentimprovement.Inparticular,lightabsorp-ofvariousNIR-IIfluorescenceandPAimagingprobesandtheirapplicationstionandscatteringfrombloodandotherarethendiscussed.Perspectivesonthepromisesandchallengesfacingthisb
