recent advances in platelet preservation and testing

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1、DatasetRecentAdvancesinPlateletPreservationandTestingDanielEricson,RaoGHR06/2013;ABSTRACTBloodplateletsplayaveryimportantroleinmaintainingnormalhemostasis.Theyhavebroadspectrumofactivitiesintheareaofbothphysiologicalfunctionsandphysiologicaldisorders.Theirroleinhemostasisinresponsetovascul

2、arinjuryiswelldocumented.Followingvascularinjurytheplateletrelatedeventsthatoccurinclude:adhesions,aggregation,secretionofgranulecontents,facilitateclotformation,helpinclotretractionandmodulatewoundhealing.Nosingleinvitrotesthasstoodoutasagoldstandardfordocumentingtheplateletfunctioneffica

3、cy.Currentlyithasbeenrecognizedthatabatterytests,whichexaminedifferentaspectsofplateletphysiology,canprovideareasonableassessmentofplateletefficacyinvivo.Currentgoldstandardforplateletperformanceisinvivosurvivaloftransfusedradiolabeledplatelets.Itisbasedmostlyontheassumption,thatviableplat

4、eletsincirculationwillmeettheirobligationandparticipateintheexpectedphysiologicalresponses.However,notmuchofclinicaldataareavailabletosupportthisassumption.Generalconsensusatpresentintheresearchcommunityisthatallthenovelproceduresavailableonplateletfunctiontestingshouldbeevaluatedagainstac

5、ceptedconventionalmethodscurrentlybeingusedinthebloodbankingpractice.Inthischapteranattempthasbeenmadetoprovideinformationonausefulpreservationmethodandasimpleplateletfunctiontestingtechnique.00 · 1BOOKMARK · 6VIEWS·Citations(0)·CitedIn(0)·Sortedby:OrderofavailabilityoOrderofavailabilityoA

6、ppearanceinpublicationDataprovidedareforinformationalpurposesonly.Althoughcarefullycollected,accuracycannotbeguaranteed.Theimpactfactorrepresentsaroughestimationofthejournal'simpactfactoranddoesnotreflecttheactualcurrentimpactfactor.PublisherconditionsareprovidedbyRoMEO.Differingprovisions

7、fromthepublisher'sactualpolicyorlicenceagreementmaybeapplicable.Page1RecentAdvancesinPlateletPreservationandTestingDanielEricsonandGunduH.R.RaoAbstractBloodplateletsplayaveryimportantroleinmaintainingnormalhemostasis.Theyhavebroadspectrumofactivitiesintheareao