Recent advances in ginseng as cancer therapeutics a functional and mechanistic overview

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1、NPRViewArticleOnlineREVIEWViewJournal

2、ViewIssueRecentadvancesinginsengascancertherapeutics:afunctionalandmechanisticoverviewCitethis:Nat.Prod.Rep.,2015,32,256abaAliceS.T.Wong,*Chi-MingCheandKar-WahLeungCovering:2000to2014Cancerisoneoftheleadingcausesofdeathworld

3、wide.Ginseng,akeyingredientintraditionalChinesemedicine,showsgreatpromiseasanewtreatmentoption.AslistedbytheU.S.NationalInstitutesofHealthasacomplementaryandalternativemedicine,itsanti-cancerfunctionsarebeingincreasinglyrecognized.Thisreviewcoversthemechanismsof

4、actionofginsenosidesandtheirmetabolites,whichcanmodulatesignalingpathwaysassociatedwithinflammation,oxidativestress,angiogenesis,metastasis,andstem/progenitor-likepropertiesofcancercells.TheemerginguseofstructurallyReceived4thJune2014modifiedginsenosidesandrecentc

5、linicalstudiesontheuseofginsengeitheraloneorincombinationDOI:10.1039/c4np00080cwithotherherbsorWesternmedicineswhichareexploitedasnoveltherapeuticstrategieswillalsobewww.rsc.org/nprexplored.1Introduction1Introduction2Ginseng2.1BriefhistoryandcurrentstatusCanceri

6、samajorglobalpublichealthproblem,andthereisan2.2Ginsenosides:majortherapeuticconstituentsofalarmingincreaseinbothitsincidenceandmortalityratesinginsengrecentyears.TheWorldHealthOrganization(WHO)showsthat2.3Pharmacokineticsin2008,anestimated12.7millionpeoplewered

7、iagnosedwith3Anti-canceractivitiescancerand7.8millionpeoplediedfromcancerworldwide.Itis3.1Inammation,macrophages,anddendriticcellsanticipatedthatby2030,anestimated21millionnewcasesof3.2Oxidativestresscancerand13.2millioncancerdeathswilloccurannuallyPublishedon2

8、7October2014.DownloadedbyGuillinUniversityofTechnologyon26/04/201503:56:13.3.3Growth,death,anddifferentiationaroundtheworld.1Currently,chemotherapyisthemainstayof3.4Angiogenesiscancertreatment.However,chemotherapyhasseveraldisad-3.4.1Angiogenicfactorsvantages:(1)

9、thedevelopmentofchemoresistanceisalmost3.4.2Endothelialprogenitorcellsinevitable;(2)althoughthesecytotoxicagentsareeffective3.5Matrixremodellingandmetastasisagainstcan