资源描述：
《Lipid Mediators inAcne -综述-文献查找-潜林芳》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、HindawiPublishingCorporationMediatorsofInflammationVolume2010,ArticleID858176,6pagesdoi:10.1155/2010/858176ReviewArticleLipidMediatorsinAcneMonicaOttaviani,EmanuelaCamera,andMauroPicardoLaboratoryofCutaneousPhysiopathology,SanGallicanoDermatologicalInstituteIRCCS,ViaElioChianes
2、i53,00144Rome,ItalyCorrespondenceshouldbeaddressedtoMauroPicardo,picardo@ifo.itReceived14May2010;Accepted6July2010AcademicEditor:ChiaraDeLucaCopyright©2010MonicaOttavianietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricted
3、use,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.Multiplefactorsareinvolvedinacnepathogenesis,andsebumsecretionisoneofthemainones.Therolesebumplaysinacnedevelopmenthasnotbeencompletelyelucidatedyet;however,increasingamountsofdataseemtoconfirmth
4、epresenceofalterationsinsebumfromacnepatients.Alteredratiobetweensaturatedandunsaturatedfattyacidshasbeenindicatedasanimportantfeaturetobeconsideredinadditiontothealteredamountofspecificfattyacidssuchaslinoleicacid.Furthermore,particularattentionhasbeenfocusedonsqualeneperoxide
5、thatseemstobeabletoinduceaninflammatoryresponsebeyondcytotoxicityandcomedonesformation.Moreover,recentdatasuggestthatlipidmediatorsareabletointerferewithsebocytesdifferentiationandsebogenesisthroughtheactivationofpathwaysrelatedtoperoxisomeproliferators-activatedreceptors.Unders
6、tandingthefactorsandmechanismsthatregulatesebumproductionisneededinordertoidentifynoveltherapeuticstrategiesforacnetreatment.1.Introductionthatsynthesiselipidsandaccumulatethemincytoplasmiclipiddroplets.Duringthefinalstagesofdifferentiation,whenAcneisaskindisorderwithmultifactor
7、ialpathogenesis.Thetheybecomefullymature,sebocytesundergodisintegrationmechanismsunderlyingitsonsetandsubsequentdevelop-andreleasetheircontent,anoilyandwaxymaterial,intomentarenotyetcompletelyclarified.Amongthefactorsthefollicle[6–9].Humansebumcontainstriglycerides,waximplicate
8、dinacneoccurrence,sebumsecretioncanbeesters,squalene,choleste
