chap03+++++AMINO+ACIDS%2C+PEPTIDES%2C

chap03+++++AMINO+ACIDS%2C+PEPTIDES%2C

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时间:2019-08-06

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1、8885d_c03_07512/23/0310:16AMPage75mac111mac111:reb:––chapter3++AMINOACIDS,PEPTIDES,ANDPROTEINS3.1AminoAcids75acids,covalentlylinkedincharacteristiclinearsequences.3.2PeptidesandProteins85Becauseeachoftheseaminoacidshasasidechainwithdistinctivechemicalproperties,this

2、groupof20pre-3.3WorkingwithProteins89cursormoleculesmayberegardedasthealphabetin3.4TheCovalentStructureofProteins96whichthelanguageofproteinstructureiswritten.3.5ProteinSequencesandEvolution106Whatismostremarkableisthatcellscanproduceproteinswithstrikinglydifferentp

3、ropertiesandactivi-tiesbyjoiningthesame20aminoacidsinmanydiffer-entcombinationsandsequences.FromthesebuildingThewordproteinthatIproposetoyou...Iwouldwishtoblocksdifferentorganismscanmakesuchwidelydiversederivefromproteios,becauseitappearstobetheproductsasenzymes,hor

4、mones,antibodies,trans-primitiveorprincipalsubstanceofanimalnutritionthatporters,musclefibers,thelensproteinoftheeye,feath-plantspreparefortheherbivores,andwhichthelatterers,spiderwebs,rhinoceroshorn,milkproteins,antibi-otics,mushroompoisons,andmyriadothersubstances

5、thenfurnishtothecarnivores.havingdistinctbiologicalactivities(Fig.3–1).Among—J.J.Berzelius,lettertoG.J.Mulder,1838theseproteinproducts,theenzymesarethemostvar-iedandspecialized.Virtuallyallcellularreactionsarecatalyzedbyenzymes.roteinsarethemostabundantbiologicalmac

6、romol-ProteinstructureandfunctionarethetopicsofthisPecules,occurringinallcellsandallpartsofcells.Pro-andthenextthreechapters.Webeginwithadescrip-teinsalsooccuringreatvariety;thousandsofdifferenttionofthefundamentalchemicalpropertiesofaminokinds,ranginginsizefromrela

7、tivelysmallpeptidestoacids,peptides,andproteins.hugepolymerswithmolecularweightsinthemillions,maybefoundinasinglecell.Moreover,proteinsexhibitenormousdiversityofbiologicalfunctionandarethe3.1AminoAcidsmostimportantfinalproductsoftheinformationpath-waysdiscussedinPar

8、tIIIofthisbook.ProteinsaretheProteinArchitecture—AminoAcidsmolecularinstrumentsthroughwhichgeneticinforma-Proteinsarepolymersofaminoacids,

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