Advances in Nutrition- An International Review Journal Volume 7 issue 4 2016 [doi 10.3945-an.115.010330] Pet, M. A.; Brouwer-Brolsma, E. M. -- The Impact of Maternal Vitamin D Status on Offspring Br

《Advances in Nutrition- An International Review Journal Volume 7 issue 4 2016 [doi 10.3945-an.115.010330] Pet, M. A.; Brouwer-Brolsma, E. M. -- The Impact of Maternal Vitamin D Status on Offspring Br》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、REVIEWTheImpactofMaternalVitaminDStatusonOffspringBrainDevelopmentandFunction:1aSystematicReview2,32MilouAPetandElskeMBrouwer-Brolsma*2DivisionofHumanNutrition,WageningenUniversity,Wageningen,Netherlands;and3DepartmentofTranslationalNeuroscience,BrainCenterD

2、ownloadedfromRudolfMagnus,UniversityMedicalCenterUtrecht,NetherlandsABSTRACTVariousstudieshaveexaminedassociationsbetweenmaternalvitaminD(VD)deficiencyandoffspringhealth,includingoffspringbrainhealth.advances.nutrition.orgThepurposeofthisreviewwastosummarizec

3、urrentevidenceconcerningtheimpactofmaternalVDdeficiencyonbraindevelopmentandfunctioninoffspring.AsystematicsearchwasconductedwithinMedline(onOvid)forstudiespublishedthrough7May2015.AnimalandhumanstudiesthatexaminedassociationsbetweenmaternalVDstatusordevelopm

4、entalVDdeficiencyandoffspringbraindevelopmentandfunctionwereincluded.Atotalof26animalstudiesand10humanstudiesmettheinclusioncriteria.SeveralanimalstudiesconfirmedthehypothesisthatlowprenatalVDstatusmayaffectbrainmorphologyandphysiologyaswellasbehavioraloutcome

5、s.Inhumans,subtlecognitiveandpsychologicalimpairmentsinoffspringofVD-deficientmotherswereobserved.However,dataobtainedfromanimalandhumanstudiesprovideinconclusiveevidence,andresultsseemtodependonstrainorraceandageofoffspring.Toconclude,prenatalVDstatusisthoug

6、httoplayanatTUFTSUNIVERSITYonJuly16,2016importantroleinbraindevelopment,cognitivefunction,andpsychologicalfunction.However,resultsareinconclusive;validationofthesefindingsandinvestigationofunderlyingmechanismsarerequired.Thus,moreinvestigationisneededbeforere

7、commendingsupplementationofVDduringpregnancytopromotebrainhealthofoffspring.AdvNutr2016;7:665–78.Keywords:maternal,prenatal,developmental,vitaminD,25(OH)D,brain,cognition,neuropsychologicalIntroductionmachinery,whichconverts25(OH)D,theinactiveVDme-Overthelas

8、tdecades,theroleofmaternalnutrientstatusintabolite,into1,25-dihydroxycholecalciferol[1,25(OH)2D3],fetaldevelopmenthasgeneratedconsiderableresearchinter-themetabolicallyactiveVDmetabolite(6).Thes