10-10 regulation of IR

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1、OverviewofImmunologyComponentsFunctionsPathologyApplicationsofISofISofIRHypersensitivityOrgansandtissuesAntigen(Ag)PreventionAutoimmunediseaseCellsImmuneResponsesImmunodeficiencyDiagnosisTumorControlmechanismsTherapyMoleculesTransplantationrejection*IS:ImmunesystemIR:ImmuneresponseMedicalImmu

2、nologyDEPARTMENTOFIMMUNOLOGY1RegulationofImmuneResponseTono-selfandchangedself:MaintaintheIRtoAgatproperlevel.Toself:Self-toleranceMedicalImmunologyDEPARTMENTOFIMMUNOLOGY2MechanismsofImmuneRegulationImmunesystemitselfNeuro-endocrinesystemMedicalImmunologyDEPARTMENTOFIMMUNOLOGY3EffectsofIm

3、muneRegulationPositiveevents:Enhancementofimmuneresponse.Negativeevents:Suppressionofimmuneresponse.MedicalImmunologyDEPARTMENTOFIMMUNOLOGY4Positiveevents:Enhancementofimmuneresponse.TargetcellsCKsTh1TcMHCCKNKAgAPCsMHCCKCKsTh2BAbPMNComplementMedicalImmunologyDEPARTMENTOFIMMUNOLOGY5Negativee

4、vents:Suppressionofimmuneresponse.TargetcellsCKsTh1TcMHCCKNKTregAgAPCMHCCKCKsTh2BAbPMNComplementMedicalImmunologyDEPARTMENTOFIMMUNOLOGY6ImmuneResponse(IR)TargetcellsCKsTh1TcMHCCKNKAgAPCsMHCCKCKsTh2BAbPMNComplementMedicalImmunologyDEPARTMENTOFIMMUNOLOGY7AgconcentrationMedicalImmunologyDEPARTME

5、NTOFIMMUNOLOGY8AntigenPresentationTargetcellsCKsTh1TcMHCCKNKAgAPCMHCCKCKsTh2BAbPMNComplementMedicalImmunologyDEPARTMENTOFIMMUNOLOGY9MHC-Agpeptidecomplexformation??MedicalImmunologyDEPARTMENTOFIMMUNOLOGY10ImmuneResponse(IR)TargetcellsCKsTh1TcMHCCKNKAgAPCMHCCKCKsTh2BAbPMNComplementMedicalImmuno

6、logyDEPARTMENTOFIMMUNOLOGY11Th1andTh2balanceIFNrTh1Th2IL-4/10++APCMedicalImmunologyDEPARTMENTOFIMMUNOLOGY12MedicalImmunologyDEPARTMENTOFIMMUNOLOGY13ImmuneResponse(IR)TargetcellsCKsTh1TcMHCCKNKTregAgAPCMHCCKCKsTh2BAbPMNComplementMedicalImmunologyDEPARTMENTOFIMMUNOLOGY14--CD4+CD25+RegulatoryTce

7、llsSelf-reactiveCD4+CD25+TcellTregcellsMedicalImmunologyDEPARTMENTOFIMMUNOLOGY15MedicalImmunologyDEPARTMENTOFIMMUNOLOGY16FunctionsofCD4+CD25+TregcellsSuppressivefunction:Producecytokines:IL-10/TGFβTregCD4+CD25+T-TinteractionCD4+CD25-TAPCMed