资源描述：
《effect of dutasteride on the riskof prostate cancer》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ThenewenglandjournalofmedicineoriginalarticleEffectofDutasterideontheRiskofProstateCancerGeraldL.Andriole,M.D.,DavidG.Bostwick,M.D.,OtisW.Brawley,M.D.,LeonardG.Gomella,M.D.,MichaelMarberger,M.D.,FrancescoMontorsi,M.D.,CurtisA.Pettaway,M.D.,TeuvoL.Tammel
2、a,M.D.,ClaudioTeloken,M.D.,Ph.D.,DonaldJ.Tindall,Ph.D.,MatthewC.Somerville,M.S.,TimothyH.Wilson,M.S.,IvyL.Fowler,B.S.N.,andRogerS.Rittmaster,M.D.,fortheREDUCEStudyGroup*ABSTRACTBackgroundFromtheDivisionofUrology,Washing-Weconductedastudytodeterminewheth
3、erdutasteridereducestheriskofincidenttonUniversitySchoolofMedicineinSt.prostatecancer,asdetectedonbiopsy,amongmenwhoareatincreasedriskfortheLouis,St.Louis(G.L.A.);BostwickLabora-tories,GlenAllen,VA(D.G.B.);theAmeri-disease.canCancerSocietyandEmoryUniver
4、sitySchoolofMedicine,Atlanta(O.W.B.);theMethodsDepartmentofUrology,KimmelCancerInthis4-year,multicenter,randomized,double-blind,placebo-controlled,parallel-Center,ThomasJeffersonUniversity,Phila-delphia(L.G.G.);theMedicalUniversityofgroupstudy,wecompare
5、ddutasteride,atadoseof0.5mgdaily,withplacebo.MenVienna,Vienna(M.M.);UniversitàVita-wereeligibleforinclusioninthestudyiftheywere50to75yearsofage,hadaSaluteSanRaffaele,Milan(F.M.);theUni-prostate-specificantigen(PSA)levelof2.5to10.0ngpermilliliter,andhadh
6、adoneversityofTexas,M.D.AndersonCancerCenter,Houston(C.A.P.);theDepartmentnegativeprostatebiopsy(6to12cores)within6monthsbeforeenrollment.Sub-ofUrology,TampereUniversityHospital,jectsunderwenta10-coretransrectalultrasound-guidedbiopsyat2and4years.Tamper
7、e,Finland(T.L.T.);UniversidadeFederalCiênciasSaúdedePortoAlegre,ResultsPortoAlegre,Brazil(C.T.);theMayoClin-ic,Rochester,MN(D.J.T.);andGlaxo-Among6729menwhounderwentabiopsyorprostatesurgery,cancerwasdetectedSmithKline,ResearchTrianglePark,NCin659ofthe33
8、05meninthedutasteridegroup,ascomparedwith858ofthe3424(M.C.S.,T.H.W.,I.L.F.,R.S.R.).Addressmenintheplacebogroup,representingarelativeriskreductionwithdutasterideofreprintrequeststoDr.AndrioleattheDi-visionofUrologicSurgery,Departm
