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大小:1.00 MB
页数:20页
时间:2019-08-04
《Continuous-Flow Syntheses of Heterocycles》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、January2011Continuous-FlowSynthesesofHeterocycles11TomaN.GlasnovandC.OliverKappe*ChristianDopplerLaboratoryforMicrowaveChemistry(CDLMC)andInstituteofChemistry,Karl-Franzens-UniversityGraz,A-8010Graz,Austria*E-mail:oliver.kappe@uni-graz.atReceivedMarch26,2010DOI10.1002/jhet.568Publishedonline7Octobe
2、r2010inWileyOnlineLibrary(wileyonlinelibrary.com).Thisreviewsurveysthesynthesisofheterocyclesundercontinuous-flowconditions,includingtheuseofchip-basedmicroreactors,coil-basedflowreactors,andcapillaryortubulardevices.J.HeterocyclicChem.,48,11(2011).ContentsPage1.Introduction112.Three-memberedringhete
3、rocycleswithoneheteroatom123.Four-memberedringheterocycleswithoneheteroatom134.Five-memberedringheterocycleswithoneheteroatom145.Five-memberedringheterocycleswithtwoheteroatoms166.Five-memberedringheterocycleswiththreeheteroatoms207.Six-memberedringheterocycleswithoneheteroatom228.Six-memberedringh
4、eterocycleswithtwoheteroatoms269.Seven-memberedringheterocycleswithoneheteroatom2710.Eight-memberedringheterocycleswithone/twoheteroatoms2711.Miscellaneousheterocycles2712.Conclusions28Referencesandnotes291.INTRODUCTIONogyapotentiallyimportanttoolfororganicchemists.Theuseofcontinuous-flowreactorsino
5、rganicsyn-Faster,easier,andreproduciblechemistrycansometimesthesisoffersmanyattractivefeaturesthathavebeenbeperformedinflowreactorswhencomparedwiththewidelyreviewed[1–3].Numerousadvantagesassociatedtraditionalround-bottomedflask.So-calledmicroreac-withtheuseofthesedeviceshaverenderedthistechnol-tiont
6、echnologyisgenerallydefinedasthecontinuous-VC2010HeteroCorporation12T.N.GlasnovandC.O.KappeVol48flowprocessingofreactionswithinstructuredchannelssis[6].Theuseofsealed/pressurizedmicrofluidicorof10–500lmdiameter.Becauseofthehighsurface-to-mesofluidiccontinuous-flowreactorsthereforeappearsvolumeratioinmic
7、rochannelsofthistype,heattransferperfectlysuitedtomimicboththerapidheatingandtheisveryefficientandreactiontemperaturesinmicroreac-hightemperaturesattainableinamicrowavechemistrytorscanbechangedefficientlybyap
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