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1、UltrasoundinMed.&Biol.,Vol.29,No.6,pp.813–823,2003Copyright©2003WorldFederationforUltrasoundinMedicine&BiologyPrintedintheUSA.Allrightsreserved0301-5629/03/$–seefrontmatterdoi:10.1016/S0301-5629(02)00776-7●OriginalContributionANOVELULTRASOUNDINDENTATI
2、ONSYSTEMFORMEASURINGBIOMECHANICALPROPERTIESOFINVIVOSOFTTISSUELIANGHAOHAN,J.ALISONNOBLEandMICHAELBURCHERMedicalVisionLaboratory,DepartmentofEngineeringScience,OxfordUniversity,Oxford,UK(Received21September2002;infinalform21November2002)AbstractTechnolog
3、iesforsofttissueanalysisareadvancingatarapidplace.Forinstance,elastography,whichprovidessofttissuestrainimages,isstartingtobetriedinclinicalpracticeasatoolfordiagnosingcancer.Softtissuedeformationmodelingandanalysisisalsoanactiveareaofresearchthathasa
4、pplicationinsurgeryplanningandtreatment.Typically,quantitativesofttissueanalysisusesnominalvaluesofsofttissuebiome-chanicalproperties.However,inpractice,softtissuepropertiescanvarysignificantlybetweenindividuals.Hence,forsofttissuemethodologiestoreacht
5、heirfullpotentialaspatient-specifictechniques,thereisaneedtodevelopwaystoefficientlymeasuresofttissuemechanicalpropertiesinvivo.Thispaperdescribesaprototypereal-timeultrasound(US)indentationtestsystemdevelopedtomeetthisneed.Thesystemisbasedontheintegrat
6、ionofaforcesensorandanopticaltrackingsystemwithacommercialUSmachineintegratedwithasuiteofanalysismethodologies.Inastudyonasingle-layerphantom,weusedthesystemtocomparevariousmethodsofestimatinglinearelasticproperties(viaatheoreticalapproximation,2-Dfini
7、teelementanalysis,3-Dfiniteelementanalysisandastandardmaterial-testingmethod).Inasecondstudyonathree-layergelatinphantom,wedescribeanewfinite-element-basedinversesolutionforrecoveringtheYoungsmoduliofeachlayertoshowhowthesystemcanestimatepropertiesofint
8、ernalcomponentsofsofttissue.Finally,weshowhowthesystemcanbeusedtoderiveamodifiedquasilinearviscoelastic(QVL)modelonrealbreasttissue.(e-mail:noble@robots.ox.ac.uk)©2003WorldFederationforUltrasoundinMedicine&Biology.KeyWords:Indentationtest,Ultra
