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1、厦门维尊生物工程有限公司一切为了健康！维生素D与贫血众所周知，维生素D不仅是一种营养素，又是一种类固醇激素。其对机体的作用除了调节钙磷代谢，还具有广泛的生物学功能。越来越多的证据显示，缺乏维生素D可能对身体极其有害，除了传统的骨矿代谢，心脏病、肺病、肿瘤、糖尿病、高血压、肥胖、精神分裂症和多发性硬化等疾病形成都与缺乏维生素D密切相关。这是一篇最新发表在《Journalofrenalnutrition》上的维生素D与贫血症的简讯。 【原文】VitaminDandAnemiaNewinsightsintothebiologicfunctio
2、nsofvitaminDincreasedtheinterestintheclinicalconsequencesofvitaminDdeficiency.Inadditiontoitsroleinmineralmetabolism,recentstudiesindicatearelationshipamonghypovitaminosisD,survival,andinflammation.Moreover,itseemsalsothatvitaminDisinvolvedinerythropoiesis.Theroleofvitam
3、inDinerythropoiesishasbeensuggestedbyseveralclinicalobservations.Inthehemodialysispopulation,vitaminDrepletionhasbeenassociatedwithdosereductionsinerythrocytestimulatingagents(ESAs)andincreasedreticulocytosis.Inchronickidneydisease(CKD)patients,improvementin25-hydroxyvit
4、aminD(25(OH)D)hasbeenassociatedwithdecreasedESArequirements.VitaminDhasbeendemonstratedtoaffectbonemarrowfunction.Moreover,levelsof厦门维尊生物工程有限公司一切为了健康！1,25-hydroxyvitaminD(1-25(OH)D),theactiveformofvitaminD,areseveralhundred-foldhigherinbonemarrowcomparedwithplasma.Despit
5、etheseintriguingobservations,thereisoverallpaucityofclinicalstudiesinvestigatingwhetheradequacyof1-25(OH)Daffectsbloodhemoglobin(Hb)levels.Patelandcolleaguesmeasuredtheconcentrationsof25(OH)D,1,25(OH)D,andHginamulticentercohortstudyof1,661subjectswithCKDintheUnitedStates
6、,ofwho41%metthecriteriaforanemia.Theyfoundthat25(OH)Dand1,25(OH)DdeficienciesareindependentlyassociatedwithdecreasedHblevelsandanemiainCKD.Theconcurrentlevelsof25(OH)DandHbof554subjectswereevaluatedinageneralpopulationaspartofnormalhealth-careoperations.Anemiawaspresenti
7、n49%of25(OH)D-deficientsubjectscomparedwith36%withnormal25(OH)Dlevels(P,.01).Theoddsratioforanemiainsubjectswith25(OH)Ddeficiencyusinglogisticregressionsandcontrollingforage,gender,andCKDwas1.9(95%confidenceinterval1.3-2.7).25(OH)D-deficientsubjectshadlowermeanHblevels(1
8、1.0vs.11.7;P5.12)andahigherprevalenceofESAuse(47%vs.24%;P,.05).Thisstudydemonstratesanassociationamongv
