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1、IrreversibleBlindnessFollowingPeriocularAutologousPlatelet-RichPlasmaSkinRejuvenationTreatment眼周富血小板血浆注射用于皮肤年轻化治疗导致永久性失明的案例分析KrishnapriyaKalyam,M.D.,ShaheenC.Kavoussi,M.D.,MichaelEhrlich,M.D.,ChristopherC.Teng,M.D.,NishaChadha,M.D.,SarahKhodadadeh,M.D.,and
2、JiLiu,M.D.Abstract:摘要：A49-year-oldwomandevelopedacutevisuallossintherighteyefollowingbilateralcosmeticplatelet-richplasmainjectionstorhytidsintheglabellarregion.Externalexamshowedskinnecrosisintheregionovertherightrhytidsandrestrictedrightocularmotility.Di
3、latedfundusexamwassignificantforophthalmicarteryocclusion.Imagingrevealedrighteyeextraocularmuscleischemiaandopticnerveinfarction,alongwithrightfrontal,parietal,andoccipitallobeinfarction.Work-upforthromboembolicandvascularetiologieswerenegative.Toourknowl
4、edge,thisisthefirstcasereportedofextensiveischemiafollowingautologousplatelet-richplasmatherapy.一位49岁的女性在双侧眉间褶皱区域注射了富含血小板血浆后出现急性的右眼视力丧失，外部检查发现右侧褶皱区域上方出现皮肤坏死、右眼球运动受限。眼底检查显示重要的眼动脉发生栓塞。成像显示右眼眼外肌缺血和视神经梗死，右额叶、顶叶和枕叶梗死。血栓形成和血管方面的病因检查是阴性的。据我们所知，这是第一例被报道的因自体富含血小板血浆
5、治疗而导致广泛缺血的病例。CASEREPORT病例报告ThecasereportedhereisincompliancewiththeHealthInsurancePortabilityandAccountabilityAct(HIPAA)regulation.Anotherwisehealthy49-year-oldwomanpresentedtotheYaleEyeCentercomplainingofacutelossofvisionintherighteyeassociatedwithseveren
6、auseaandeyepain.Onedayprior,thepatientunderwentanautologousplatelet-richplasma(APRP)injectionprocedurebyanunlicensedpractitionertoreducewrinklesintheglabellarregionbilaterally.Shereportedthatbloodwastakenfromherantecubitalregionbyvenouspunctureandcentrifug
7、edtoobtainconcentratedautologousplasma.Bilateralforeheadrhytidsinjectionswereperformed.Thepatientwasunawarethedetailsoftheplasmapreparationandthesizeofneedlethatwasusedforinjections.Shetoleratedthefirstinjectionontheleftsidewell.However,duringthesecondinje
8、ctionatthenasalendofrighteyebrow,shefelttheneedlepenetrateslightlydeeper,accompaniedbysuddenpainandfullnessbehindherrighteyewithimmediatevisuallossoverthenextfewminutes.Shethennotedtransientimprovementofvisio
