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ID:40479233
大小:742.10 KB
页数:50页
时间:2019-08-03
《抑那通治疗前列腺癌的新进展》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、抑那通治疗前列腺癌的新进展AUA(2010)内分泌治疗新进展Radiotherapycombinedwithandrogendeprivationvs.androgendeprivationaloneinclinicallylocallyadvancedprostatecanerinamulticenterrandomisedphaseIIIstudyNicolasMottet,France.AUA(2010)内分泌治疗新进展INTRODUCTIONANDOBJECTIVESInlocallyadvanceddisease,thecomb
2、inationofradiotherapy(RT)andandrogendeprivation(ADT)issuperiortoRTalone.ButADTwithananaloguehasneverbeencomparedtocombinedmodality.WereportaphaseIIIrandomisedtrialinlocallyadvancedPCa,comparingacombinedmodalityandADTonly.AUA(2010)内分泌治疗新进展METHODSInthisFrenchmulticenter,ope
3、n,randomisedtrial,patientslessthan80years,withhistologicallyconfirmedPCa,T3-4,orpT3(biopsy)N0M0wereincluded.Theywerecentrallyrandomisedin2parallelgroupstoeitherADTalone(leuprorelin11.25mgSR,1scinjectionevery3monthsfor3yearsorthesameADTcombinedwithRTstartingwithin3monthsov
4、er7weeks.AUA(2010)内分泌治疗新进展RESULTSHTHT+RTPN131133MeanAge70.570.70.63MeanPSAbaseline51.7741.500.79MedianPFS(days)126425440.0005PFS(5year)(%)15.464.70.0005Biologicalprogression(%)71.519.5<0.0001Clinicalprogression(%)37.711.3<0.0001AUA(2010)内分泌治疗新进展Prevalenceofmetabolicsyndro
5、meinprostatecancerpatientsunderandrogendeprivationtherapy:interimresultsofacase-controlstudy.JorgeRopero,Barcelone,Spain.AUA(2010)内分泌治疗新进展INTRODUCTIONANDOBJECTIVESCardiovascularmortalityisthemostimportantcauseofdeathinpatientswithprostatecancer(PC).Thedevelopmentofmetabol
6、icsyndrome(MS)inpatientsundergoingandrogendeprivationtherapy(ADT)hasbeenrelatedwiththisincreaseinmortalityrate.TheaimofthisstudyhasbeentoconfirmthehypothesisthatADTincreasestheprevalenceofMS.AUA(2010)内分泌治疗新进展METHODSAgroupof157patientswereenrolledinthisinterimanalysisofapr
7、ospectivecasecontrolstudy.53PCpatientsunderADTduringameantimeof52months(6to252)and104agematchedcontrolsevaluatedatthetimeofprostatebiopsy(52withcancerand52without)wereincluded.AUA(2010)内分泌治疗新进展METHODSMSwasanalyzedaccordingtheATPIIIpanelcriteria:Fastingplasmaglucoselevel>1
8、10mg/dLserumtriglyceridelevel>150mg/dLserumhigh-densitylipoproteinlevel<40mg/dLwaistcircumferenc
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